Repeated Administration of Cocaine Alters Dopamine Uptake and Release in the Striatum Nucleus Accumbens(a)

Annals of the New York Academy of Sciences
L H ClayK F Soliman

Abstract

Male Sprague-Dawley rats were administered 25 mg/kg, intraperitoneally (i.p.) cocaine-HCl twice daily for 14 consecutive days (total of 50 mg/kg), while control animals received an equivalent volume of 0.9% saline. After three days of withdrawal, the animals were sacrificed for dissection of striatal (STR) and nucleus accumbens (NA) brain regions. The treated group demonstrated a dose-dependent reduction for in vitro cocaine inhibition of [3H]dopamine (DA) uptake in the NA tissue verses controls. There were no significant differences amongst the treated and control groups for in vitro cocaine inhibition of [(3)H]DA in the STR. In vitro d-amphetamine (1, 5 and 10 μM)-stimulated DA release from STR tissue was not significantly different between the treated and the control groups. However, there was a significant decline in basal STR DA release and a significant enhancement of d-amphetamine (1 and 5 μM)-stimulated DA release in the NA for the treatment group versus controls. The results from the present study indicates sensitization to cocaine is primarily related to DA uptake and release in the NA.

References

Jul 1, 1991·Trends in Neurosciences·M J KuharJ W Boja
May 1, 1989·Mechanisms of Ageing and Development·M G KoltaR W Hart
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·H O Pettit, J B Justice
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J Peris, N R Zahniser
May 1, 1985·Pharmacology, Biochemistry, and Behavior·L C GuanJ B Becker
May 1, 1980·Pharmacology, Biochemistry, and Behavior·D C RobertsH C Fibiger
Dec 1, 1995·Journal of Neurochemistry·M F Suaud-ChagnyF Gonon
Jan 1, 1993·Psychopharmacology·M R WeedW L Woolverton
Mar 1, 1994·Brain Research. Molecular Brain Research·C CerrutiM J Kuhar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.