Repeated airway constrictions in mice do not alter respiratory function

Journal of Applied Physiology
Samuel Mailhot-LaroucheYnuk Bossé

Abstract

It is suggested that the frequent strain the airways undergo in asthma because of repeated airway smooth muscle (ASM)-mediated constrictions contributes to airway wall remodeling. However, the effects of repeated constrictions on airway remodeling, as well as the ensuing impact of this presumptive remodeling on respiratory mechanics, have never been investigated in subjects without asthma. In this study, we set out to determine whether repeated constrictions lead to features that are reminiscent of asthma in mice without asthma. BALB/c mice were subjected to a 30-min constriction elicited by aerosolized methacholine every other day over 6 wk. Forty-eight hours after the last constriction, the mechanics of the respiratory system was evaluated at baseline and in response to incremental doses of nebulized methacholine with the flexiVent. The whole-lung lavages, the tracheas, and the lungs were also collected to evaluate inflammation, the contractile capacity of ASM, and the structural components of the airway wall, respectively. The resistance and the compliance of the respiratory system, as well as the Newtonian resistance and the resistive and elastic properties of the lung tissue, were not affected by repeated constrictions, bo...Continue Reading

References

Jan 1, 1992·Journal of Applied Physiology·Z HantosJ J Fredberg
Aug 1, 1994·Journal of Applied Physiology·A BaiM Okazawa
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·M A SwartzJ M Drazen
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·D J Tschumperlin, J M Drazen
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel J TschumperlinJeffrey M Drazen
Dec 9, 2003·Journal of Applied Physiology·Scott WagersJason H T Bates
Feb 14, 2004·American Journal of Respiratory Cell and Molecular Biology·Eric Careau, Elyse Y Bissonnette
Mar 18, 2005·Nature·Jose G VenegasR Scott Harris
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eric CareauElyse Y Bissonnette
Jun 1, 2007·The European Respiratory Journal·I S T BosJ Zaagsma
Jun 17, 2008·The Journal of Allergy and Clinical Immunology·Sandra D Anderson, Pascale Kippelen
Mar 27, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S OhtaM Adachi
May 26, 2010·Experimental Lung Research·Eric CareauElyse Y Bissonnette
Jun 8, 2010·The European Respiratory Journal·J CortijoE J Morcillo
May 27, 2011·The New England Journal of Medicine·Christopher L GraingePeter H Howarth
Sep 3, 2011·The European Respiratory Journal·A KoaraiL E Donnelly
Oct 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda L TatlerGisli Jenkins
Oct 26, 2013·American Journal of Respiratory Cell and Molecular Biology·Loes E M KistemakerReinoud Gosens
Oct 9, 2015·Annals of the American Thoracic Society·Luke J JanssenPaul M O'Byrne
Jun 10, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Loes E M KistemakerReinoud Gosens
Jun 18, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kruti R PatelXingbin Ai
Sep 8, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Katrina Dean, Robert Niven

❮ Previous
Next ❯

Citations

Aug 18, 2018·The European Respiratory Journal·Reinoud Gosens, Nicholas Gross
Jun 5, 2019·Journal of Applied Physiology·Roberta SüdyFerenc Peták
Aug 20, 2019·Expert Review of Respiratory Medicine·Mario CazzolaPaola Rogliani
Feb 1, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Michael J O'Sullivan, Bo Lan
May 7, 2020·Frontiers in Pediatrics·Michael B Anthracopoulos, Mark L Everard
Aug 8, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Punnam Chander VeeratiChris L Grainge
Jul 4, 2018·Biomechanics and Modeling in Mechanobiology·Michael R HillBindi S Brook
Dec 2, 2020·Open Biology·Michael J O'SullivanJin-Ah Park
Apr 7, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lennart K A Lundblad, Annette Robichaud
Dec 22, 2020·ACS Pharmacology & Translational Science·Nicolas M ZahnLeggy A Arnold

❮ Previous
Next ❯

Methods Mentioned

BETA
lavages

Software Mentioned

Quick Prime
ImageJ
Prism
GraphPad
NDP View

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Physiology. Lung Cellular and Molecular Physiology
Timothy D Le CrasGurjit K Khurana Hershey
American Journal of Physiology. Lung Cellular and Molecular Physiology
F R ShardonofskyAladin M Boriek
The Journal of Allergy and Clinical Immunology
Salman SiddiquiChristopher Brightling
© 2022 Meta ULC. All rights reserved