PMID: 11328452May 1, 2001Paper

Repeated antenatal glucocorticoid treatment decreases hypothalamic corticotropin releasing hormone mRNA but not corticosteroid receptor mRNA expression in the fetal guinea-pig brain

Journal of Neuroendocrinology
L McCabeStephen G Matthews

Abstract

Approximately 10% of pregnant women are treated with synthetic glucocorticoids in late gestation, to promote fetal lung maturation. The effectiveness of this treatment has led to the use of repeated dose regimens, with little knowledge of the impact on neuroendocrine development. Animal studies have recently shown that repeated fetal glucocorticoid exposure can lead to permanent changes in hypothalamic-pituitary-adrenal (HPA) function in offspring. In this study, we hypothesized that such treatment modifies corticotropin releasing hormone (CRH), glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) systems in the developing limbic system and hypothalamus. Pregnant guinea-pigs were treated with dexamethasone, betamethasone or vehicle on days 40,41,50,51,60 and 61 of gestation (birth = 68 days). On day 62, guinea-pigs were killed and the fetuses rapidly removed. Glucocorticoid treatment resulted in a dose-dependent reduction in plasma cortisol concentrations in both male and female fetuses. There was also a significant reduction in CRH mRNA expression in the hypothalamic paraventricular nucleus. In contrast, exposure to glucocorticoid increased MR mRNA expression in the hippocampus (CA1/2 and CA3) and dentate gyrus of ...Continue Reading

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Citations

Jun 21, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hanna SchöpperSusanne Huber
Mar 12, 2004·Brain Research. Developmental Brain Research·Marcus H AndrewsStephen G Matthews
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·Stephen G Matthews
May 7, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·A L Fowden, A J Forhead
May 28, 2014·Nature Reviews. Endocrinology·Vasilis G Moisiadis, Stephen G Matthews
May 28, 2014·Nature Reviews. Endocrinology·Vasilis G Moisiadis, Stephen G Matthews
Feb 14, 2006·The Journal of Physiology·Amita KapoorStephen G Matthews
Feb 19, 2008·Pediatric Neurology·Susan L ConnorsAndrew W Zimmerman
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·Dawn OwenStephen G Matthews
Dec 24, 2011·American Journal of Obstetrics and Gynecology·Matthias SchwabPeter W Nathanielsz
Oct 18, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Andrea ConstantinofStephen G Matthews
Jun 28, 2016·Neuroscience and Biobehavioral Reviews·Nils C GassenAnthony S Zannas
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Marcus H Andrews, Stephen G Matthews
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Jul 9, 2016·The Journal of Endocrinology·K S WilsonM A Denvir
Dec 26, 2018·Journal of Neuroendocrinology·Hirotaka Hamada, Stephen G Matthews

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