Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus

Pediatric Research
Jessica SunJ Kurtzberg

Abstract

Babies with congenital hydrocephalus often experience developmental disabilities due to brain injury associated with prolonged increased pressure on the developing brain parenchyma. Umbilical cord blood (CB) infusion has favorable effects in animal models of brain hypoxia and stroke and is being investigated in clinical trials of brain injury in both children and adults. We sought to establish the safety and feasibility of repeated intravenous infusions of autologous CB in young babies with congenital hydrocephalus. Infants with severe congenital hydrocephalus and an available qualified autologous CB unit traveled to Duke for evaluation and CB infusion. When possible, the CB unit was utilized for multiple infusions. Patient and CB data were obtained at the time of infusion and analyzed retrospectively. From October 2006 to August 2014, 76 patients with congenital hydrocephalus received 143 autologous CB infusions. Most babies received repeated doses, for a total of two (n = 45), three (n = 18), or four (n = 4) infusions. There were no infusion-related adverse events. As expected, all babies experienced developmental delays. Cryopreserved CB products may be effectively manipulated to provide multiple CB doses. Repeated intraveno...Continue Reading

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Citations

Jan 8, 2018·Molecular Neurobiology·Dominika GładyszKamil K Hozyasz
Aug 9, 2017·Developmental Medicine and Child Neurology·Nienke WagenaarFrank van Bel
May 19, 2019·International Journal of Molecular Sciences·Dariusz BoruczkowskiIzabela Zdolińska-Malinowska
Feb 13, 2020·F1000Research·Samata Singhi, Michael Johnston
Feb 3, 2021·British Journal of Haematology·Andromachi Scaradavou

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