PMID: 8938551Nov 1, 1996Paper

Repeated bile acid therapy for the long-term management of cholesterol gallstones

Journal of Hepatology
M L PetroniT C Northfield

Abstract

Following non-surgical treatment, cholesterol gallstones recur in a high proportion of patients, and recurrence cannot be predicted nor effectively prevented. Our aim was to test prospectively the viability and the efficacy of repeated bile acid therapy, in which recurrent stones are diagnosed at an early stage by regular ultrasound monitoring and promptly retreated, as a strategy for the management of these patients in clinical practice. One hundred and seventy-two consecutive patients were recruited upon achieving complete gallstone dissolution using non-surgical therapy (bile acids or lithotripsy plus bile acids), and followed up at 6-monthly intervals by ultrasound scan. Gallstone recurrence was promptly treated by a combination of ursodeoxycholic acid plus chenodeoxycholic acid (5 mg/kg per day each) for a period of 2 years, or less if complete redissolution was achieved. Median follow-up period was 34 months (range 6-70). Forty-five patients had gallstone recurrence; of these, 39 underwent one or more repeated courses of bile acid therapy (follow-up data available in 27). Gallstone recurrence rate was 15% at 1 year and 47% at 5 years. Average annual redissolution rate of recurrent gallstones (intention to treat) was 41%. ...Continue Reading

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Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TomidaT Osuga
Sep 17, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A LanziniF Benini
Mar 7, 2008·World Journal of Gastroenterology : WJG·Claudia Della CorteRaffaele Iorio
May 12, 2012·World Journal of Gastrointestinal Pharmacology and Therapeutics·Piero PortincasaDavid Qh Wang
Feb 25, 2006·Scandinavian Journal of Gastroenterology·Michael Sackmann
May 19, 2010·Gastroenterology Clinics of North America·Agostino Di CiaulaPiero Portincasa

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