Repeated Binge Drinking Increases Perineuronal Nets in the Insular Cortex

Alcoholism, Clinical and Experimental Research
Hu ChenAmy W Lasek

Abstract

Alcohol exposure leads to changes in the extracellular matrix (ECM) in the brain, which profoundly impacts neuronal plasticity. Perineuronal nets (PNs) are specialized ECM structures that enclose subpopulations of neurons in the cortex. Adolescent exposure to alcohol induces long-lasting increases in the expression of PN components in the cortex in adult mice. However, it has not been determined whether binge alcohol exposure in young adults alters PNs. Here, we examined PNs and their core components in the insula and primary motor cortex after repeated binge-like ethanol (EtOH) consumption in adult mice. The 4-day drinking in the dark (DID) procedure was performed in mice for 1 or 6 weeks to model binge alcohol consumption. The impact of EtOH drinking on PNs was examined by fluorescent staining of brain sections using a marker for PNs, Wisteria floribunda agglutinin (WFA). In another set of experiments, cortex was dissected and Western blots and real-time quantitative polymerase chain reaction were performed to evaluate the expression of the PN proteins aggrecan, brevican, and phosphacan. Binge-like EtOH drinking for 6 weeks caused a significant increase in PNs in the insula, as measured by WFA binding. Aggrecan, brevican, and...Continue Reading

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Citations

Apr 27, 2016·Biological Psychiatry·Byron K Y BitanihirweTsung-Ung W Woo
May 14, 2016·Trends in Neurosciences·Patrick J MulhollandPeter W Kalivas
Sep 2, 2016·Alcoholism, Clinical and Experimental Research·Amy W Lasek
Aug 23, 2019·Addiction Biology·Hu Chen, Amy W Lasek
Feb 15, 2020·Alcoholism, Clinical and Experimental Research·Linda Patia Spear
Sep 2, 2017·Frontiers in Integrative Neuroscience·Wolfgang HärtigDominik Michalski
Feb 17, 2021·Journal of Psychiatric Research·Edith V SullivanAdolf Pfefferbaum
Jan 1, 2018·Trends in Genetics : TIG·Amy W LasekWei-Yang Chen
Mar 7, 2021·International Journal of Molecular Sciences·Daniela Carulli, Joost Verhaagen
Feb 7, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Weiping SuLarry S Sherman

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