Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception.

Neuropharmacology
Adrianne R WilsonMichael M Morgan

Abstract

Cannabinoids and opiates inhibit pain, in part, by activating the periaqueductal gray (PAG). Evidence suggests this activation occurs through distinct mechanisms. If the antinociceptive mechanisms are distinct, then cross-tolerance between opioids and cannabinoids should not develop. This hypothesis was tested by measuring the antinociceptive effect of microinjecting morphine into the ventrolateral PAG of rats pretreated with the cannabinoid HU-210 for two days. Male Sprague-Dawley rats were injected twice a day for two days with vehicle (0.4 microL), morphine (5 microg/0.4 microL), HU-210 (5 microg/0.4 microL), or morphine combined with HU-210 into the ventrolateral PAG. Repeated injections of morphine caused a rightward shift in the morphine dose-response curve on Day 3 (i.e., tolerance developed). No tolerance was evident in rats pretreated with morphine combined with HU-210. In rats pretreated with HU-210 alone, morphine antinociception was enhanced. This enhancement was blocked by pretreating rats with the cannabinoid receptor antagonist AM-251, and it also disappeared when rats were tested one week later. Acute microinjection of HU-210 into the PAG antagonized morphine antinociception, suggesting that HU-210-induced enhan...Continue Reading

References

Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·T SuzukiS Yanaura
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·F ZambottiP Mantegazza
Aug 26, 1999·Life Sciences·J M WalkerK Tsou
Sep 29, 2001·Current Opinion in Investigational Drugs·A S Rice
Sep 23, 2003·Pain·Ozgur YesilyurtOguzhan Yildiz
Jun 24, 2005·Nature·Andrea G HohmannDaniele Piomelli
Dec 27, 2005·European Journal of Pharmacology·John D RobertsMargaret Shih
Feb 14, 2006·Brain Research·Jian-Ping GongGeorge R Uhl
Apr 25, 2006·The Journal of Pain : Official Journal of the American Pain Society·Michael M MorganMelissa M King
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·Michael M MorganSusan L Ingram
Nov 23, 2006·Behavioural Brain Research·Scott A BernalRebecca M Craft
Apr 11, 2007·The European Journal of Neuroscience·Liana FattoreDaniela Parolaro

❮ Previous
Next ❯

Citations

Feb 22, 2011·Neuroscience·R MaldonadoP Robledo
Nov 26, 2009·Brain Research·Jillian L ScavoneElisabeth J Van Bockstaele
Oct 2, 2009·Peptides·Richard J Bodnar
Jul 15, 2009·British Journal of Pharmacology·Daniela da Fonseca PachecoIgor Dimitri Gama Duarte
Sep 6, 2015·The International Journal of Neuropsychopharmacology·Marie FitzgibbonMichelle Roche
Mar 21, 2012·British Journal of Pharmacology·Stefania MerighiPier Andrea Borea
Oct 16, 2012·Pharmacology, Biochemistry, and Behavior·Adrianne R Wilson-PoeMichael M Morgan
Mar 16, 2012·Brain Research·Alianda Maira CornélioMichael M Morgan
Feb 12, 2013·The Journal of Pain : Official Journal of the American Pain Society·Lori N Eidson, Anne Z Murphy
Mar 23, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne NielsenBernard Le Foll
Mar 14, 2020·Mini Reviews in Medicinal Chemistry·Ercan Ozdemir
Sep 18, 2018·Cannabis and Cannabinoid Research·Beth Wiese, Adrianne R Wilson-Poe
Apr 20, 2017·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Aline Carolina GiardiniMarucia Chacur
Dec 17, 2009·Expert Opinion on Pharmacotherapy·Dana TurcotteMike Namaka
Jan 11, 2021·Advances in Biological Regulation·Pratibha MalhotraMarco Falasca
Feb 23, 2021·Frontiers in Nutrition·Risa TakemotoRyuji Takahashi
May 8, 2020·Pharmacology, Biochemistry, and Behavior·Manuella Machado GodoiJanaina Menezes Zanoveli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.