Repeated Chlamydia trachomatis genital infections in adolescent women.

The Journal of Infectious Diseases
Byron E BatteigerJ D Fortenberry

Abstract

Repeated Chlamydia trachomatis infections are common among young sexually active women. The relative frequency of reinfection and antibiotic treatment failure is undefined. Adolescent women enrolled in a longitudinal cohort had behavioral and sexually transmitted infection assessments performed every 3 months, including amplification tests for C. trachomatis, ompA genotyping, and interviews and diary entries to document sex partner-specific coitus and event-specific condom use. Repeated infections were classified as reinfection or treatment failure by use of an algorithm. All infections for which treatment outcomes were known were used to estimate the effectiveness of antibiotic use. We observed 478 episodes of infection among 210 study participants; 176 women remained uninfected. The incidence rate was 34 episodes/100 woman-years. Of the women who were infected, 121 experienced 1 repeated infections, forming 268 episode pairs; 183 pairs had complete data available and were classified using the algorithm. Of the repeated infections, 84.2% were definite, probable, or possible reinfections; 13.7% were probable or possible treatment failures; and 2.2% persisted without documented treatment. For 318 evaluable infections, we estimat...Continue Reading

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Citations

Jun 5, 2010·The Journal of Infectious Diseases·Byron E BatteigerMichael L Rekart
Mar 30, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Kamelia M OsmanHussein M Galal
Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William M GeislerJohn Caminis
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Aug 16, 2013·Sexually Transmitted Diseases·David G ReganJane S Hocking
Oct 12, 2013·Sexually Transmitted Diseases·Ana RadovicGina S Sucato
Mar 11, 2010·Sexually Transmitted Diseases·Kenneth H FifeJ Dennis Fortenberry
Aug 17, 2011·Sexually Transmitted Diseases·Jennifer L KernsCarolyn L Westhoff
Oct 14, 2011·Sexually Transmitted Diseases·H Hunter Handsfield
Jan 18, 2012·Sexually Transmitted Diseases·Rebecca GuyJohn M Kaldor
Apr 17, 2012·Sexually Transmitted Diseases·Mirjam KretzschmarStuart Berman
Nov 30, 2012·Sexually Transmitted Diseases·Erika WikströmHeljä-Marja Surcel
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Nov 5, 2010·The Journal of Sexual Medicine·Michael ReeceJ Dennis Fortenberry
Feb 20, 2013·La Presse médicale·Bertille de Barbeyrac

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