PMID: 9523566Apr 2, 1998Paper

Repeated cocaine administration alters extracellular glutamate in the ventral tegmental area

Journal of Neurochemistry
P W Kalivas, P Duffy

Abstract

The present study determined if repeated cocaine injections alter the effect of cocaine on extracellular glutamate in the ventral tegmental area (VTA). All rats were treated with daily cocaine (15 mg/kg i.p. x 2 days, 30 mg/kg i.p. x 5 days) or saline for 7 days. At 21 days after discontinuing the daily injections, a dialysis probe was placed into the VTA and the extracellular levels of glutamate were estimated. A systemic injection of cocaine (15 mg/kg i.p.) elevated extracellular glutamate in the VTA of rats pretreated with daily cocaine but not in the daily saline-pretreated subjects. No significant change in glutamate was produced by a saline injection in either pretreatment group. In a group of rats pretreated with daily cocaine, the D1 antagonist SCH-23390 (30 microM) was infused through the dialysis probe prior to the acute injections of saline and cocaine. SCH-23390 prevented the increase in extracellular glutamate associated with the acute administration of cocaine. Behavioral data were collected simultaneously with the measures of extracellular glutamate. The behavioral stimulant effect of cocaine was greater in cocaine-pretreated than saline-pretreated subjects, and the behavioral augmentation in cocaine-pretreated r...Continue Reading

Citations

Oct 30, 2001·Journal of Addictive Diseases·J L Cornish, P W Kalivas
Nov 19, 2003·The European Journal of Neuroscience·Maria S Brenz VercaJean-Luc Dreyer
Apr 15, 2011·Pharmacological Reviews·Jeffery D Steketee, Peter W Kalivas
Dec 17, 2011·Annals of the New York Academy of Sciences·Marisela Morales, Virginia M Pickel
Nov 26, 2015·Frontiers in Neuroscience·Manoranjan S D'Souza
Mar 5, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Barbara Juarez, Ming-Hu Han
Jul 10, 2002·Annals of the New York Academy of Sciences·José A CrespoE Ambrosio
Apr 30, 2003·Journal of Neurochemistry·Wen-Xue TangScott E Hemby
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emilio Fernandez-EspejoRocio Moreno-Paublete
Jun 15, 2007·Genes, Brain, and Behavior·C W HodgeS P Kelley
May 13, 2003·Molecular Psychiatry·T M Tzschentke, W J Schmidt
Nov 17, 2004·Neurotoxicity Research·Sari Izenwasser
Jan 23, 2016·Behavioral and Brain Functions : BBF·Hyopil KimBong-Kiun Kaang
Jun 18, 2019·Current Neuropharmacology·Irena SmagaMałgorzata Filip
Jan 30, 2020·International Journal of Molecular Sciences·Maria Carolina Velasquez-MartinezCarlos A Jimenez-Rivera
May 22, 2001·Experimental Biology and Medicine·K K ParkK F Soliman
Jun 2, 2005·Journal of Neurophysiology·Arthur AronLucy L Brown
Jan 16, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Heidi KemppainenKalervo Kiianmaa
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karin Magendzo, Gonzalo Bustos
Jun 18, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xinchun JinAthina Markou
Feb 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chiung-Chun HuangKuei-Sen Hsu
Jan 29, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Elliott RobinsonC J Malanga

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