Repeated cross-sectional sero-monitoring of SARS-CoV-2 in New York City.

Nature
Daniel StadlbauerFlorian Krammer

Abstract

In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in China and has since caused a pandemic of coronavirus disease 2019 (COVID-19). The first case of COVID-19 in New York City was officially confirmed on 1 March 2020 followed by a severe local epidemic1. Here, to understand seroprevalence dynamics, we conduct a retrospective, repeated cross-sectional analysis of anti-SARS-CoV-2 spike antibodies in weekly intervals from the beginning of February to July 2020 using more than 10,000 plasma samples from patients at Mount Sinai Hospital in New York City. We describe the dynamics of seroprevalence in an 'urgent care' group, which is enriched in cases of COVID-19 during the epidemic, and a 'routine care' group, which more closely represents the general population. Seroprevalence increased at different rates in both groups; seropositive samples were found as early as mid-February, and levelled out at slightly above 20% in both groups after the epidemic wave subsided by the end of May. From May to July, seroprevalence remained stable, suggesting lasting antibody levels in the population. Our data suggest that SARS-CoV-2 was introduced in New York City earlier than previously documented and desc...Continue Reading

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Citations

Jan 10, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Amy K FeehanLeonardo Seoane
Jan 7, 2021·Nature Reviews. Immunology·Marc Veldhoen, J Pedro Simas
Feb 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Rahul SubramanianMercedes Pascual
Feb 16, 2021·Frontiers in Immunology·Stephan SchlickeiserLeif G Hanitsch
Feb 10, 2021·Nature Communications·Rachel E BakerBryan T Grenfell
Jan 5, 2021·Frontiers in Medicine·Juliana GonçalvesHelena Soares
Mar 11, 2021·The New England Journal of Medicine·Florian KrammerViviana Simon
Mar 19, 2021·Journal of Cellular and Molecular Medicine·Monica NeaguAristidis Tsatsakis
Mar 13, 2021·The Journal of Physiology·David Cabrera-GarciaNeil L Harrison
Apr 30, 2021·Vox Sanguinis·Antoine LewinUNKNOWN Surveillance, Risk Assessment, Policy, the Virology Sub-groups of the ISBT Transfusion Transmitted Infectious Diseases Worki
Apr 19, 2021·The Lancet. Respiratory Medicine·Andrew G LetiziaStuart C Sealfon
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Jun 10, 2021·Nature Communications·Matthew M HernandezEmilia Mia Sordillo
May 18, 2021·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Antoine LewinGilles Delage
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Apr 28, 2021·Epidemiology and Infection·Jaya Singh KshatriSanghamitra Pati
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Sep 19, 2021·BMC Pregnancy and Childbirth·Nadia CharepeE Fátima Serrano

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Methods Mentioned

BETA
nucleic acid amplification
enzyme-linked immunosorbent assay
ELISA
PCR
Transfection
electrophoresis
ELISAs

Software Mentioned

Excel
GraphPad Prism

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