Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats

Behavioural Brain Research
Luanna M P FernandesCristiane S F Maia

Abstract

Binge-like ethanol intake (BEI) is a socioeconomical problem among adolescents and increasingly affects women. BEI can leave a long-term imprint in the brain, but it is unknown if its effect on cognition and anxiety is cumulative on repeated binge-ethanol episodes. We now submitted female Wistar rats to repeated cycles of binge-like ethanol treatment by intragastrically administering ethanol (3.0 g/kg/day, 20% w/v ethanol; 3 days on/4 days off) starting at postnatal day 35 (PND35). To investigate the short-term effects of BEI during adolescence, rats underwent 1 or 4 cycles of BEI, being evaluated at PND37 and PND58, respectively: both groups displayed anxiety-like behavior in the open field and elevated plus-maze tests, as well as short-term memory deficits in the object recognition task; this was associated with transient decreases of BDNF levels and increases of GFAP levels in the hippocampus. To evaluate the short- and long-lasting effects of BEI in adulthood, rats were subjected to 8 cycles of BEI and evaluated after 7.5 h (PND86) or after 14 days of ethanol withdrawal (PND100). This caused a persistent anxiogenic profile whereas recognition memory was impaired on the short-term, but not 14 days post-administration. The re...Continue Reading

Citations

Jul 3, 2019·The Journal of Pharmacology and Experimental Therapeutics·Shivendra D ShuklaRonald J Korthuis
Oct 18, 2018·Oxidative Medicine and Cellular Longevity·Luanna Melo Pereira FernandesCristiane Socorro Ferraz Maia
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Dinair Pamplona-SantosRafael Rodrigues Lima
Aug 18, 2020·Oxidative Medicine and Cellular Longevity·Chirlene Pinheiro NascimentoCristiane Socorro Ferraz Maia
May 30, 2020·International Journal of Molecular Sciences·Micaele Maria Lopes CastroRafael Rodrigues Lima
Feb 11, 2020·Frontiers in Behavioral Neuroscience·Rodrigo G MiraWaldo Cerpa
Nov 10, 2020·Alcoholism, Clinical and Experimental Research·Cristiane do Socorro Ferraz MaiaRafael Rodrigues Lima
Aug 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cristiane MaiaRafael Rodrigues Lima

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