Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP)

Drug and Chemical Toxicology
D E MalekG A Wright

Abstract

Twenty-eight day feeding studies were conducted to evaluate the repeated dose toxicity of NMP, a widely used industrial solvent, in Crl:CD BR rats and B6C3F1 mice. Groups of 5 male and 5 female rats each were fed either 0, 2,000, 6,000, 18,000, or 30,000 ppm NMP; similar groups of mice were fed either 0, 500, 2,500, 7,500, or 10,000 ppm. In vivo parameters, hematology and clinical chemistry parameters, and complete pathology evaluations were conducted after approximately 28 days. Decrements in mean body weight gains, reflecting decreases in food consumption and efficiency, were seen in male rats fed 18,000 ppm and in both sexes fed 30,000 ppm. In rats, clinical chemical changes, indicating possible compound-related alterations in lipid, protein, and carbohydrate metabolism, occurred at 18,000 ppm in males and 30,000 ppm in both sexes. No histopathological changes in rats were judged to be directly related to NMP exposure. Hematological (mild to moderate leukopenia) and histopathological alterations (hypocellular bone marrow, testicular degeneration and atrophy, and thymic atrophy) were judged to be secondary to nutritional and body weight effects in male and/or female rats at 30,000 ppm. In mice, cloudy swelling of the epitheli...Continue Reading

References

Aug 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K P LeeP W Schneider
Mar 1, 1982·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P J BecciL W Burnette

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Citations

Apr 18, 2015·BMC Nephrology·Kathy MacJeffrey Wong
Nov 30, 2006·International Journal of Occupational Medicine and Environmental Health·Krystyna Sitarek, Anna Kilanowicz
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·A M SaillenfaitA M Lambert-Xolin
Sep 1, 2017·Biomedical Materials·Kevin RobertsJeffrey C Wolchok
Sep 2, 2015·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Bekanntmachung des Umweltbundesamtes

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