Repeated doses of sucrose in infants continue to reduce procedural pain during prolonged hospitalizations

Nursing Research
Denise HarrisonLinda Johnston

Abstract

The efficacy of oral sucrose in the reduction of single episodes of acute procedural pain in newborn infants has been demonstrated in a large number of well-conducted randomized controlled trials. However, there are few studies that have examined the effectiveness of repeated doses of sucrose and there are no studies of prolonged sucrose use in sick infants over an entire period of hospitalization. The aim of this study was to evaluate the analgesic effectiveness of repeated doses of oral sucrose during heel lancing in sick infants over the course of a prolonged hospitalization. A prospective longitudinal cohort study was conducted in a tertiary referral neonatal intensive care unit. Infants with a predicted length of stay of > or =28 days were eligible for inclusion. Oral sucrose was administered prior to and during all heel lance procedures observed. Pain outcomes consisted of facial expression scores, crying duration, heart rate, and oxygen saturation. Changes in sequential pain responses were analyzed, and weighted linear regression slopes for all assessed parameters were calculated to estimate the average regression slope. There were 55 infants enrolled, and 443 pain assessments during heel lancing were conducted. Behavior...Continue Reading

References

Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Mar 1, 1987·Pain·Ruth V E Grunau, Kenneth D Craig
May 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·J A Rushforth, M I Levene
Mar 1, 1996·The Clinical Journal of Pain·B StevensA Taddio
Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·L A RamenghiM I Levene
Jun 2, 1998·Journal of Pediatric Surgery·S JayanthiM D Stringer
Jul 11, 1998·Archives of Disease in Childhood·P J LewindonN Lewindon
Feb 24, 2001·Developmental Medicine and Child Neurology·S GormallyS N Young
Dec 5, 2002·Nursing Research·Sharyn GibbinsGerarda Darlington
Nov 12, 2003·Archives of Pediatrics & Adolescent Medicine·Evelyn Cohen ReisRichard Holubkov
Nov 25, 2003·Journal of Paediatrics and Child Health·D HarrisonP Loughnan
Dec 4, 2003·Wiener klinische Wochenschrift·Klaudia RohrmeisterArnold Pollak
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·A B AcharyaD Field
Aug 4, 2004·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·V MucignatF Gold
Feb 21, 2006·Journal of Paediatrics and Child Health·Denise HarrisonLinda Johnston
Apr 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Denise HarrisonLinda Johnston

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Pain and Headache Reports·Denise HarrisonBonnie Stevens
Dec 4, 2012·Journal of Pain Research·Nour MekkaouiAmina Barkat
Feb 9, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Carlo V BellieniGiuseppe Buonocore
Sep 4, 2012·Early Human Development·Adriana Cardoso Rodrigues, Ruth Guinsburg
Dec 10, 2013·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Susan O'Conner-Von, Helen N Turner
May 31, 2011·Journal of Pain and Symptom Management·Jen-Jiuan LiawMeei-Horng Yang
Dec 9, 2010·Early Human Development·Denise HarrisonLinda Johnston
Jul 31, 2016·International Journal of Nursing Studies·Haixia GaoDanwen Wang
Oct 26, 2010·Pain·C Celeste JohnstonMarsha Campbell-Yeo
May 6, 2015·The Cochrane Database of Systematic Reviews·Denise HarrisonBonnie Stevens
Jun 17, 2011·Pediatric Radiology·Andrea D Edwards, Owen J Arthurs
Jul 16, 2016·The Cochrane Database of Systematic Reviews·Bonnie StevensAllyson Shorkey
Nov 30, 2011·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Ananda FernandesC Celeste Johnston
Aug 31, 2019·Nursing Children and Young People·Esra Ardahan AkgülHatice Yildirim Sari
Apr 18, 2012·Pediatrics·John W HarringtonRosemarie Santos
Oct 10, 2012·Pediatrics·Denise HarrisonBonnie Stevens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.