Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization.

Addiction Biology
Raúl PastorTamara J Phillips

Abstract

Neuroadaptations supporting behavioral sensitization to abused drugs are suggested to underlie pathological, excessive motivation toward drugs and drug-associated stimuli. Drug-induced sensitization has also been linked to increased appetitive responses for non-drug, natural reinforcers. The present research investigated whether ethanol (EtOH)-induced neural changes, inferred from psychomotor sensitization, can modify consumption and intake dynamics for the natural reinforcer, sucrose. The effects of EtOH-induced sensitization in mice on the temporal structure of sucrose intake patterns were measured using a lickometer system. After sensitization, sucrose intake dynamics were measured for 1 hour daily for 7 days and indicated more rapid initial approach and consumption of sucrose in EtOH-sensitized groups; animals showed a shorter latency to the first intake bout and an increased number of sucrose bottle licks during the initial 15 minutes of the 1-hour sessions. This effect was associated with increased frequency and size of bouts. For the total 1-hour session, sucrose intake and bout dynamics were not different between groups, indicating a change in patterns of sucrose intake but not total consumption. When sensitization was ...Continue Reading

References

Dec 17, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·J CottM Lindqvist
Jan 1, 1992·Annual Review of Psychology·N M White, P M Milner
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·J Masur, R Boerngen
Jul 1, 1994·The International Journal of Eating Disorders·C C HoldernessM P Warren
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·T J PhillipsC N Lessov
Apr 16, 1998·Psychopharmacology·C N Lessov, T J Phillips
Mar 5, 1999·Behavioural Pharmacology·C J Harmer, G D Phillips
Apr 25, 2000·Neuron·J D Berke, S E Hyman
Jun 3, 2000·Annals of Internal Medicine·J G WieseW S Browner
Sep 1, 2000·Alcoholism, Clinical and Experimental Research·R Sinha, S S O'Malley
Jan 1, 1993·Behavioural Pharmacology·J. Stewart, A. Badiani
Nov 3, 2001·Brain Research. Brain Research Reviews·B J EverittT W Robbins
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Nicole M Avena, Bartley G Hoebel
Apr 25, 2003·Alcoholism, Clinical and Experimental Research·Christina N Lessov, Tamara J Phillips
Jan 22, 2005·Current Opinion in Pharmacology·J D SalamoneS M Weber
Jul 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen K SzumlinskiPeter W Kalivas
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Matthew M FordDeborah A Finn
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Suzanne H MitchellTamara J Phillips
Mar 25, 2006·Annals of Neurology·Andrew H EvansPaola Piccini
Jun 9, 2006·Addiction Biology·Carla Sanchis-Segura, Rainer Spanagel
Feb 6, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R E NordquistL J M J Vanderschuren
Mar 22, 2007·Alcoholism, Clinical and Experimental Research·Darin J KnappGeorge R Breese
Jul 10, 2007·Neuroscience and Biobehavioral Reviews·Nicole M AvenaBartley G Hoebel
Aug 2, 2007·PloS One·Magalie LenoirSerge H Ahmed
Mar 18, 2008·British Journal of Pharmacology·M J ThomasY Shaham
May 20, 2008·Drug and Alcohol Dependence·Matthew M FordDeborah A Finn
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Raúl PastorTamara J Phillips
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Terry E Robinson, Kent C Berridge

❮ Previous
Next ❯

Citations

Sep 10, 2014·Expert Opinion on Drug Discovery·Tamara J Phillips, Cheryl Reed
Oct 30, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Erica N GrodinReza Momenan
Jul 5, 2012·Alcoholism, Clinical and Experimental Research·Valentina VengelieneRainer Spanagel
Jan 13, 2015·Alcoholism, Clinical and Experimental Research·Noah R GubnerTamara J Phillips
Jul 1, 2014·Behavioural Brain Research·Emily C EastwoodTamara J Phillips
Apr 21, 2016·Brain Research Bulletin·Rosana Camarini, Ricardo Marcos Pautassi
Mar 31, 2015·Pharmacology, Biochemistry, and Behavior·Jennifer K RoebberNirupa Chaudhari
Jul 20, 2018·Acta Microbiologica Et Immunologica Hungarica·Ayat MoradipourFatemeh Piri
Nov 23, 2018·Frontiers in Psychiatry·David A WissPedro Rada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.