Repeated exposure of male mice to low doses of lipopolysaccharide: dose and time dependent development of behavioral sensitization and tolerance in an automated light-dark anxiety test

Behavioural Brain Research
Tomek J BanasikowskiMartin Kavaliers

Abstract

Although lipopolysaccharide (LPS) is widely used to examine immune behavior relationships there has been little consideration of the effects of low doses and the roles of sensitization and, or tolerance. Here low doses of LPS (1.0, 5.0 and 25.0 μg/kg) were peripherally administered to male mice on Days 1, 4, 28 and 32 after a baseline recording of anxiety-like behaviors in an automated light-dark apparatus (total time in the light chamber, number of light-dark transitions, nose pokes into the light chamber). LPS at 1.0 μg/kg, while having no significant effects on anxiety-like behaviors in the light-dark test on Days 1 and 4, displayed sensitization with the mice exhibiting significantly enhanced anxiety-like responses on Days 28 and 32. LPS at 5.0 μg/kg had no consistent significant effects on anxiety-like behavior on Days 1 and 4, with sensitization and enhanced anxiety-like behaviors on Day 28 followed by tolerance on Day 32. LPS at 25 μg/kg significantly enhanced anxiety-like behaviors on Day 1, followed by tolerance on Day 4, which was not evident by Day 28 and re-emerged on Day 32. There was a similar overall pattern of sensitization and tolerance for LPS-induced decreases in locomotor activity in the safe dark chamber, w...Continue Reading

References

Jan 1, 1990·Neuroscience and Biobehavioral Reviews·B L Hart
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J N Crawley
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·B L Hart
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Apr 2, 1998·Physiology & Behavior·D SoszynskiM J Kluger
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·A Aubert
Mar 22, 2001·Brain, Behavior, and Immunity·R Dantzer
Feb 20, 2002·Trends in Neurosciences·Jan Pieter KonsmanRobert Dantzer
Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John D JohnsonSteven F Maier
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Christopher G EngelandKlaus-Peter Ossenkopp
Mar 15, 2003·Stress : the International Journal on the Biology of Stress·Shawn HayleyHymie Anisman
Apr 5, 2003·Brain, Behavior, and Immunity·Hymie AnismanShawn Hayley
Apr 12, 2003·Psychoneuroendocrinology·A BartolomucciS Parmigiani
May 12, 2005·Journal of Neuroimmunology·Ru ChenSulie L Chang
Mar 21, 2007·Brain, Behavior, and Immunity·J L TeelingV H Perry
Mar 24, 2007·Frontiers in Neuroendocrinology·Alessandro Bartolomucci
May 12, 2009·Behavioural Brain Research·David J SandersonJ Nicholas P Rawlins
Sep 29, 2009·Trends in Immunology·Subhra K Biswas, Eduardo Lopez-Collazo
Dec 23, 2009·Brain, Behavior, and Immunity·Rachel A KohmanAlexander W Kusnecov
Oct 1, 2011·Psychological Science·Martin Kavaliers, Elena Choleris
Dec 7, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Matthew Morris, Liwu Li
Dec 17, 2011·Psychoneuroendocrinology·Jason R Yee, Brian J Prendergast
Aug 18, 2012·Behavioural Brain Research·Andrew J TarrNing Quan
Feb 26, 2014·Brain, Behavior, and Immunity·Ning Quan
Jan 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael D WeberSteven F Maier
Jan 23, 2015·Frontiers in Immunology·Matthew C MorrisLiwu Li

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