PMID: 653741Feb 1, 1978Paper

Repeated exposure to acrolein vapour: subacute studies in hamsters, rats and rabbits

Toxicology
V J FeronH R Immel

Abstract

The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 h/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal irritation, growth depression and histopathological changes of the respiratory tract in each of the animal species exposed. The aberrations in the airways consisted of destruction and hyper- and metaplasia of the lining epithelium accompanied by inflammatory alterations. Rats appeared to be the most susceptible of the species examined and showed treatment-related abnormalities even at 0.4 ppm, whereas this exposure level was found to be a no-toxic effect level in both hamsters and rabbits.

References

Jun 1, 1975·Atmospheric Environment·N E HesterO C Taylor

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Citations

Oct 1, 1992·Journal of Applied Toxicology : JAT·R A ParentJ E Long
Dec 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·V E Steele, J T Arnold
Apr 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K Ramos, L R Cox
Dec 4, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P M VanscheeuwijckE L Carmines
Mar 17, 1999·Toxicology Letters·N ArumugamH Devaraj
Apr 11, 1997·Journal of Toxicology and Environmental Health·M G MénacheF J Miller
Dec 18, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard M LoPachinTerrence Gavin
Jan 30, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel L MorganScott M Palmer
Jun 3, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael T BorchersJay W Tichelaar
Aug 8, 2009·American Journal of Respiratory and Critical Care Medicine·Hitesh S DeshmukhGeorge D Leikauf
Apr 14, 2007·Environmental Health Perspectives·Tracey J WoodruffDaniel A Axelrad
Aug 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph A CichockiJohn B Morris
Nov 5, 2014·Cutaneous and Ocular Toxicology·Shlomit DachirTamar Kadar
Aug 19, 2015·The Science of the Total Environment·M TrantallidiP Carrer
Oct 24, 2007·Experimental and Molecular Pathology·Michael T BorchersGeorge D Leikauf
Oct 14, 2011·Molecular Nutrition & Food Research·Kiflai Bein, George D Leikauf
Oct 1, 1984·Toxicology and Applied Pharmacology·J M PatelC I Hood
Jul 1, 1984·Toxicology and Applied Pharmacology·L A BuckleyC S Barrow
Jul 6, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Josje H E ArtsRuud A Woutersen
Sep 17, 2003·Journal of Applied Toxicology : JAT·P M TerpstraG Patskan
Mar 13, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·R Philip YeagerHans Rosenfeldt
May 16, 2002·Chest·George D LeikaufLeigh G Simpson
Jan 1, 1985·Critical Reviews in Toxicology·R O BeauchampH D Heck
Jan 1, 1991·Critical Reviews in Toxicology·P M BosP C Bragt
Apr 2, 2013·Nutritional Neuroscience·Pinar Erkekoglu, Terken Baydar
Nov 29, 2008·Toxicology and Industrial Health·O FaroonD J Plewak
Nov 26, 2008·Toxicology and Industrial Health·O FaroonD J Plewak
Apr 28, 2005·Journal of Applied Toxicology : JAT·Bryan Ballantyne, Raymond E Schroeder
Feb 27, 2008·Inhalation Toxicology·David C DormanGabrielle A Willson
Feb 27, 2008·Inhalation Toxicology·Melanie F StruveDavid C Dorman
Apr 1, 1990·Environmental Health Perspectives·B A Gaskell
Dec 26, 2018·The Laryngoscope·Xinxin LiuM Preeti Sivasankar
Apr 1, 1990·Environmental Health Perspectives·T M MonticelloL Uraih
Sep 14, 1999·The American Journal of Physiology·M T BorchersG D Leikauf
May 12, 1998·The American Journal of Physiology·M T BorchersG D Leikauf
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Todd StedefordChing-Hung Hsu
Nov 24, 1999·Journal of Applied Physiology·J B MorrisG Gianutsos
Aug 10, 2020·Environment International·Todd BlessingerDavid Bussard

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