Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle

Journal of Applied Physiology
Paul S HafenRobert D Hyldahl

Abstract

The heat stress response is associated with several beneficial adaptations that promote cell health and survival. Specifically, in vitro and animal investigations suggest that repeated exposures to a mild heat stress (~40°C) elicit positive mitochondrial adaptations in skeletal muscle comparable to those observed with exercise. To assess whether such adaptations translate to human skeletal muscle, we produced local, deep tissue heating of the vastus lateralis via pulsed shortwave diathermy in 20 men and women ( n = 10 men; n = 10 women). Diathermy increased muscle temperature by 3.9°C within 30 min of application. Immediately following a single 2-h heating session, we observed increased phosphorylation of AMP-activated protein kinase and ERK1/2 but not of p38 MAPK or JNK. Following repeated heat exposures (2 h daily for 6 consecutive days), we observed a significant cellular heat stress response, as heat shock protein 70 and 90 increased 45% and 38%, respectively. In addition, peroxisome proliferator-activated receptor gamma, coactivator-1 alpha and mitochondrial electron transport protein complexes I and V expression were increased after heating. These increases were accompanied by augmentation of maximal coupled and uncoupled...Continue Reading

Associated Clinical Trials

Feb 2, 2021·Jayson Gifford

References

Aug 1, 1971·The American Journal of Physiology·G A BrooksR E Beyer
Dec 1, 1968·Journal of Applied Physiology·B SaltinJ A Stolwijk
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J O Holloszy, E F Coyle
Jun 1, 1996·Journal of Applied Physiology·R J SpinaJ O Holloszy
Sep 25, 1999·The New England Journal of Medicine·P L Hooper
Jun 14, 2000·Journal of Applied Physiology·W W WinderJ O Holloszy
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJohn O Holloszy
Dec 23, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne McArdleMalcolm J Jackson
Mar 16, 2005·The Journal of Biological Chemistry·Takayuki AkimotoZhen Yan
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair
Dec 7, 2005·Medicine and Science in Sports and Exercise·Mark A Tarnopolsky, Sandeep Raha
Oct 19, 2007·European Journal of Applied Physiology·Chad TouchberryPhilip Gallagher
Jul 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah M SenfAndrew R Judge
May 27, 2009·The International Journal of Biochemistry & Cell Biology·Erich Gnaiger
Nov 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Vladimir B RitovDavid E Kelley
Aug 16, 2011·Physiology·Carles Cantó, Johan Auwerx
Aug 27, 2011·Annals of Medicine·Gerald Pfeffer, Patrick F Chinnery
Nov 5, 2011·Journal of Applied Physiology·Chien-Ting Liu, George A Brooks
Mar 17, 2012·Dose-response : a Publication of International Hormesis Society·Yasir Hasan SiddiqueMohammad Afzal
May 9, 2012·Fibrogenesis & Tissue Repair·Aparna VidyasagarArjang Djamali
May 16, 2012·The Journal of Physiology·Steen LarsenMartin Hey-Mogensen
Jan 22, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chieh-Chung LiuHsiao-Chuan Wen
Jun 4, 2013·Journal of Athletic Training·David O DraperJustin H Rigby
Oct 11, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ana C RondaRicardo Boland
Dec 3, 2013·Biochimica Et Biophysica Acta·Aaron P RussellGlenn D Wadley
Aug 1, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuki TamuraHideo Hatta
Dec 30, 2014·Medicine and Science in Sports and Exercise·Craig PorterBlake B Rasmussen
Apr 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Sandra I Rosado MontillaJoshua T Selsby

❮ Previous
Next ❯

Citations

May 11, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Katie HeskethMatthew Cocks
Jan 24, 2020·Journal of Applied Physiology·Kyoungrae KimBruno T Roseguini
May 1, 2020·Journal of Applied Physiology·Kyoungrae KimBruno T Roseguini
May 22, 2020·Experimental Physiology·Bent R RønnestadCarsten Lundby
Jul 10, 2020·Journal of Applied Physiology·Robert D Hyldahl, Jonathan M Peake
Sep 1, 2020·European Journal of Applied Physiology·Patrick RodriguesGeoffrey M Minett
Jul 14, 2020·Exercise and Sport Sciences Reviews·Kyoungrae KimBruno T Roseguini
Aug 9, 2020·Frontiers in Physiology·Mohammed IhsanSebastien Racinais
Nov 8, 2020·European Journal of Applied Physiology·Mariem LabidiSébastien Racinais
Oct 2, 2020·Journal of Applied Physiology·Tom CullenC Douglas Thake
Sep 25, 2020·Journal of Applied Physiology·Alex T Von SchulzePaige C Geiger
Oct 30, 2020·Journal of Applied Physiology·James J McCormickGlen P Kenny
Jan 31, 2021·International Journal of Environmental Research and Public Health·Kaemmer N HendersonHunter S Waldman
Apr 2, 2021·Journal of Applied Physiology·Vienna E Brunt, Christopher T Minson
Jun 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·David O'SullivanErika L Pearce
Aug 19, 2021·Physiological Reports·Pierre-Emmanuel Tardo-DinoAlexandra Malgoyre
Aug 8, 2021·Experimental Gerontology·Rhonda P Patrick, Teresa L Johnson
Sep 7, 2021·The Journal of Physiology·Robert D HyldahlJayson R Gifford
Jun 10, 2021·Medicine and Science in Sports and Exercise·Kyoungrae KimBruno T Roseguini

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
transgenic

Software Mentioned

JMP Pro
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.