PMID: 11314682Apr 21, 2001Paper

Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats

Psychopharmacology
C E BeyerJeffery D Steketee

Abstract

Toluene is a solvent found in many commercial products and is frequently abused by inhalation. Whether previous exposure to toluene alters subsequent responses to other drugs of abuse is not known. This study determined the effects of repeated toluene exposure on the acute motor-stimulant response to cocaine and on cocaine-induced dopamine (DA) concentrations in the nucleus accumbens (NAc). One week following bilateral cannulae implantation over the NAc, 27 adult, male Wistar rats began a daily 30-min exposure regimen to either toluene (8,000 ppm) or air for ten sessions. Approximately 24 h or 96 h after their last exposure, animals were injected with either saline or cocaine (15 mg/kg, i.p.) and locomotor activity and DA concentrations in the NAc were measured. Exposure to toluene rendered the rats immobile, and the time required for recovery of normal posture decreased across the ten sessions. In all animals tested, systemic cocaine administration enhanced both locomotor activity and DA concentrations in the NAc. These increases, however, were significantly greater in rats previously exposed to toluene. Overall, these findings show that repeated toluene exposure enhances behavioral and neurochemical responses to subsequent co...Continue Reading

Citations

Sep 27, 2003·European Journal of Pharmacology·Madina R GerasimovRobert L Balster
Apr 23, 2003·Life Sciences·Jenny L WileyRobert L Balster
Jun 16, 2010·Experimental and Clinical Psychopharmacology·Matthew S HerbertSanders A McDougall
Aug 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob T Beckley, John J Woodward
Jan 11, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arthur C RiegelEdward D French
Apr 15, 2011·Pharmacological Reviews·Jeffery D Steketee, Peter W Kalivas
Sep 17, 2013·Neurotoxicology and Teratology·Michelle L TomaszyckiScott E Bowen
Apr 10, 2010·Systems Biology in Reproductive Medicine·John H Hannigan, Scott E Bowen
Jul 14, 2010·Pharmacology, Biochemistry, and Behavior·Jeffery C BatisScott E Bowen
Feb 9, 2010·Pharmacology, Biochemistry, and Behavior·Scott E BowenSusan Irtenkauf
Dec 2, 2008·Neurotoxicology and Teratology·Scott E BowenPatrick B Cooper
Sep 18, 2007·Neurotoxicology and Teratology·Scott E BowenJenny L Wiley
Mar 12, 2008·British Journal of Pharmacology·D I LubmanA J Lawrence
Oct 3, 2006·Alcoholism, Clinical and Experimental Research·Nagisa AoyamaNorio Ozaki
Oct 27, 2006·Neurotoxicology and Teratology·Scott E BowenSilvia L Cruz
Sep 29, 2006·Neurotoxicology and Teratology·Przemysław NowakRyszard Brus
May 6, 2006·Drug and Alcohol Dependence·Dianne E LeeAndrew N Gifford
Jul 3, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jhodie Rubina DuncanAndrew John Lawrence
Jul 6, 2014·Psychopharmacology·Aaron K ApawuScott E Bowen
Jun 5, 2021·Neurotoxicology and Teratology·Silvia L Cruz, Scott E Bowen

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