PMID: 7539097Mar 1, 1995Paper

Repeated exposure to lindane leads to behavioral sensitization and facilitates electrical kindling

Neurotoxicology and Teratology
M E Gilbert

Abstract

Repeated intermittent exposure to some chemicals produces behavioral sensitization and seizure induction through a kindling mechanism. Although many pesticides are convulsant at high dosages, the persistent neurological effects of chronic low level exposure are unclear. The impact of intermittent exposure to lindane on behavioral seizure development and subsequent electrical kindling was assessed in the present study. Rats were administered lindane (0 or 10 mg/kg, po) for 30 days, or 3 times/week for 10 weeks. Enhanced behavioral responsiveness to lindane (myoclonic jerks, clonic seizures) emerged over the course of dosing and persisted 2 to 4 weeks after the last dose. The incidence of generalized convulsions was increased from 0% to 15% between the first and final day of dosing. In addition, electrographic recordings from the amygdala revealed brief rhythmic bursts and isolated interictal spike and wave discharge in the absence of overt behavioral seizures. Electrical kindling of the amygdala, beginning 4 to 6 weeks after the final dose, was facilitated. In contrast, prior administration of a single convulsive dose of lindane (20 mg/kg) was without effect on kindling development. These data indicate that repeated exposure to ...Continue Reading

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Citations

Mar 1, 1995·Neurotoxicology and Teratology·M E Gilbert, C M Mack
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Glenn D RitchieJohn Rossi
May 15, 1998·Neurotoxicology and Teratology·S RiveraC Sanfeliu
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Oct 11, 2005·Toxicology·Sylvie CloutierBarbara A Sorg
Jul 7, 2007·Human & Experimental Toxicology·Virginia C Moser
Feb 13, 2019·Chemistry : a European Journal·Flora L Thorp-GreenwoodMichaele J Hardie
May 10, 2002·Annals of the New York Academy of Sciences·M E Gilbert
Jul 19, 2018·Neurotoxicology·Mar RequenaRaquel Alarcón

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