Repeated exposure to MDMA and amphetamine: sensitization, cross-sensitization, and response to dopamine D₁- and D₂-like agonists.

Psychopharmacology
Sarah BradburyS Schenk

Abstract

Acute exposure to (±) 3, 4-methylenedioxymethamphetamine (MDMA) produces hyperlocomotion that is preferentially expressed in the periphery of closed chambers. Following repeated administration, however, a sensitized hyperlocomotor response is preferentially expressed in the center of an activity box, so that the response resembles the more generalized activity that is produced by D-amphetamine (AMPH). The present study was designed to determine whether common neuroadaptations underlie the acute and sensitized responses to MDMA and AMPH. Rats were pretreated with five daily injections of MDMA (10.0 mg/kg), AMPH (2.0 mg/kg), or saline. Following a 2-day drug-free period, dose-response curves for hyperactivity produced by MDMA (2.5-10.0 mg/kg), AMPH (0.5-2.0 mg/kg), SKF-81297 (1.0-2.0 mg/kg), or quinpirole (0.25-1.0 mg/kg) were obtained. Effects of MDMA and AMPH were increased by pretreatment with both drugs. The sensitized response following MDMA exposure was preferentially expressed in the center compartment, but, following AMPH pretreatment, the sensitized response was observed in both compartments. Cross-sensitization was unidirectional; AMPH pretreatment failed to sensitize to the effects of MDMA, but MDMA pretreatment sensit...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G Rudnick, S C Wall
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D LévesqueP Sokoloff
Nov 26, 1991·Behavioural Brain Research·D EilamH Szechtman
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·D Eilam, H Szechtman
Feb 28, 1989·European Journal of Pharmacology·D Eilam, H Szechtman
Apr 27, 1988·European Journal of Pharmacology·G BattagliaE B De Souza
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·L M Adams, M A Geyer
Jan 1, 1974·The Journal of Pharmacy and Pharmacology·B Costall, R J Naylor
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·D S Segal, A J Mandell
May 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N L RempelM A Geyer
Jul 1, 1993·Pharmacology, Biochemistry, and Behavior·J BrodkinJ F Nash
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Aug 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H KehneC J Schmidt
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·C Van Hartesveldt
May 8, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P W KalivasS R White
Nov 9, 2000·European Journal of Pharmacology·K C Morley, I S McGregor
May 2, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H S CrombagT E Robinson
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Taco J De VriesLouk J M J Vanderschuren
Apr 26, 2002·Neuroreport·Karen K Szumlinski, Henry Szechtman
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neil M RichtandS Paul Berger
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronan DepoortereBernard Scatton
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Evangelene DanielaSusan Schenk

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Citations

Mar 25, 2014·British Journal of Pharmacology·A R GreenK C F Fone
Mar 12, 2015·Pharmacology, Biochemistry, and Behavior·Susan Schenk, Sarah Bradbury
Jun 7, 2016·Pharmacology, Biochemistry, and Behavior·Susan SchenkJeremy Webster
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Sep 14, 2018·Psychopharmacology·Quenten Highgate, Susan Schenk
Aug 27, 2021·Pharmacology, Biochemistry, and Behavior·Sanders A McDougallLaura L Cotter

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