PMID: 2499148May 1, 1989Paper

Repeated GH-releasing hormone administration unravels different GH secretory patterns in normal adults and children

Acta Endocrinologica
E GhigoF Camanni

Abstract

In normal adults, repeated GHRH administration leads to progressively decreasing somatotrope responses. To verify whether this GH secretory pattern also connotes normal growing children, we have studied the effects of two consecutive (every 120 min) 1 microgram/kg iv GHRH boluses on GH release in normal adults (N = 7, age 23.2-30.6 years) children (N = 6, age 10.4-13.2 years). In the adults, the GH response to the second GHRH bolus (peak, mean +/- SEM; 2.9 +/- 0.8 micrograms/l) was lower (P less than 0.02) than that to the first bolus (15.9 +/- 2.4 micrograms/l). Conversely, in children the GH response to the second GHRH bolus (25.6 +/- 6.3 micrograms/l) overrode the first one (13.6 +/- 6.5 micrograms/l), but this difference did not attain statistical significance. In adults cholinergic enhancement by pyridostigmine, a cholinesterase inhibitor, was previously shown to re-instate, even to potentiate somatotrope responsiveness to consecutive GHRH boluses. Thus, in 5 children GH response to repeated GHRH boluses was retested administering pyridostigmine (60 mg orally) 30 min before the second GHRH bolus. In these subjects, pyridostigmine failed significantly to potentiate the GH responsiveness to the second GHRH bolus (30.3 +/- 4....Continue Reading

Citations

Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M CappaP Borrelli
Apr 6, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R CoyaP Martul
Apr 30, 1999·Journal of Psychiatric Research·R K StøvingC Hagen
Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Oct 14, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A SartorioE E Muller
Jan 1, 1992·Metabolism: Clinical and Experimental·E GhigoF Camanni
Aug 1, 1991·Clinical Endocrinology·A SartorioG De Nicolao
May 22, 2007·Stress : the International Journal on the Biology of Stress·D JezovaM Vigas
Oct 1, 1995·Journal of Endocrinological Investigation·A SartorioG Faglia
Jul 9, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·A VelaM A Busturia

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