Repeated High Rate Facet Capsular Stretch at Strains That are Below the Pain Threshold Induces Pain and Spinal Inflammation With Decreased Ligament Strength in the Rat

Journal of Biomechanical Engineering
Sonia KarthaBeth A Winkelstein

Abstract

Repeated loading of ligamentous tissues during repetitive occupational and physical tasks even within physiological ranges of motion has been implicated in the development of pain and joint instability. The pathophysiological mechanisms of pain after repetitive joint loading are not understood. Within the cervical spine, excessive stretch of the facet joint and its capsular ligament has been implicated in the development of pain. Although a single facet joint distraction (FJD) at magnitudes simulating physiologic strains is insufficient to induce pain, it is unknown whether repeated stretching of the facet joint and ligament may produce pain. This study evaluated if repeated loading of the facet at physiologic nonpainful strains alters the capsular ligament's mechanical response and induces pain. Male rats underwent either two subthreshold facet joint distractions (STFJDs) or sham surgeries each separated by 2 days. Pain was measured before the procedure and for 7 days; capsular mechanics were measured during each distraction and under tension at tissue failure. Spinal glial activation was also assessed to probe potential pathophysiologic mechanisms responsible for pain. Capsular displacement significantly increased (p = 0.019)...Continue Reading

References

Feb 1, 1976·The Journal of Trauma·R D Crowninshield, M H Pope
Jun 1, 1967·The Journal of Physiology·P R Burgess, E R Perl
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Mar 29, 1997·Lancet·A Yassi
Jul 10, 1998·Journal of Spinal Disorders·M M PanjabiM Vahldiek
Jul 29, 1999·The American Journal of Sports Medicine·S L WooM A Janaushek
Jan 5, 2000·Clinical Biomechanics·M M PanjabiJ Cholewicki
Nov 15, 2000·Journal of Shoulder and Elbow Surgery·R G PollockV C Mow
Jul 2, 2003·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·M SolomonowA Gedalia
Apr 20, 2004·Spine·Adam M PearsonManohar M Panjabi
May 19, 2005·Journal of Biomechanics·Kathryn E LeeBeth A Winkelstein
Jun 4, 2005·American Journal of Public Health·Donald C ColeHarry S Shannon
Jul 20, 2005·The European Journal of Neuroscience·Misbah Malik-HallJon D Levine
Dec 31, 2005·Journal of Neurosurgery. Spine·Brian D StemperFrank A Pintar
Apr 6, 2006·The Journal of Bone and Joint Surgery. American Volume·John M CavanaughSrinivasu Kallakuri
Aug 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Chaoyang ChenJohn M Cavanaugh
Aug 8, 2006·Muscle & Nerve·Daniel NavarMoshe Solomonow
Apr 12, 2007·Journal of Occupational and Environmental Medicine·Peter LeVikas Patel
Aug 21, 2007·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Michael W OlsonMoshe Solomonow
Feb 19, 2009·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Nadia R AzarJohn M Cavanaugh
Mar 31, 2009·The Journal of Pain : Official Journal of the American Pain Society·Kathryn E Lee, Beth A Winkelstein
Jun 23, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Spencer P LakeLouis J Soslowsky
Aug 26, 2009·Clinical Biomechanics·Karen KingMoshe Solomonow
Jan 23, 2010·Scandinavian Journal of Work, Environment & Health·Rogier M van RijnAlex Burdorf
Oct 25, 2011·Spine·Michele CuratoloBeth A Winkelstein
Apr 24, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Stephen F E MattucciDuane S Cronin
Jul 9, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hassam A BaigBeth A Winkelstein
Oct 8, 2013·The Journal of Pain : Official Journal of the American Pain Society·Ling DongBeth A Winkelstein
Jul 16, 2014·Journal of Biomechanics·G MatteiA Ahluwalia
Aug 5, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Timothy J BonnerSpyros D Masouros

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Citations

Mar 7, 2019·Journal of Biomechanical Engineering·Victor H Barocas, Beth A Winkelstein

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