PMID: 1641240Jun 1, 1992Paper

Repeated infection of cats with Brugia pahangi: parasitological observations

Parasitology
D A DenhamA Smail

Abstract

Cats were repeatedly inoculated with infective larvae of Brugia pahangi. On parasitological grounds they could be divided into 5 groups. Group I--most cats (some 70%) became microfilaraemic (mf+) and retained high levels of microfilariae (mf) in their blood for over 2 years. In some Group I cats mf counts stabilized at high levels whilst in others mf counts continued to increase. Large numbers of fecund adult worms were recovered from their lymphatics. Adult counts were not made on the cats in the current experiments but over 100 adults have been recovered from 'super-susceptible' cats. Large amounts of B. pahangi adult antigen were consistently present in the serum of all Group I cats. About 30% of cats became amicrofilaraemic (mf-). In these cats the peak mf levels were seldom above 10,000 mf/ml. Group II--these cats had less than 10,000 mf/ml and low antigen levels. After more than 1 year of being repeatedly infected B. pahangi adult antigen slowly declined and eventually could no longer be detected in their serum and the number of mf declined very slowly after the fall in antigen levels. This shows that in Group II cats the adult worms die and as the cats are resistant to the development of the continuing weekly inoculation...Continue Reading

References

Nov 1, 1972·International Journal for Parasitology·D A DenhamF Guy
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A DenhamF Guy
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·E A Ottesen

Citations

Dec 3, 1999·Parasite Immunology·E SartonoM Yazdanbakhsh
Jun 15, 1999·Experimental Parasitology·R G BellT R Klei
May 1, 1993·Parasite Immunology·C I BaldwinD A Denham
Jul 5, 2013·Clinical Microbiology Reviews·C Paul MorrisEdward Mitre
Mar 10, 1998·Parasite Immunology·A Kurniawan-AtmadjaR M Maizels

Related Concepts

Antigens, Helminth
Brugia
Felis catus
Filarial Elephantiases
Microfilaria

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