Repeated injection of MK801: an animal model of schizophrenia?

Neurochemistry International
Elvar M EyjolfssonUrsula Sonnewald

Abstract

Glutamate-induced neurotoxicity plays an important role in neurological and psychiatric diseases. Thus, much attention has been given to the potential neuroprotective role of glutamate receptor antagonists, especially to those acting on the N-methyl-d-aspartate (NMDA) subtype. However, in addition to their neuroprotective potential, these compounds have also neurotoxic and psychotogenic properties. In the present study we used repeated injections of MK801 to examine if this non-competitive NMDA receptor antagonist could be used to produce schizophrenia-like alterations in behavior and brain metabolism in animals. Rats were given injections of MK801 (0.1 mg/kg) on six consecutive days, the last dose together with [1-(13)C]glucose and [1,2-(13)C]acetate, to probe neuronal and astrocytic metabolism, respectively. Analyses of extracts from parts of the frontal cortex plus cingulate and retrosplenial cortices and temporal lobes were performed using (13)C and (1)H magnetic resonance spectroscopy. Changes in glutamate and glutamine were restricted to the temporal lobe, in which amounts and labeling from [1-(13)C]glucose and [1,2-(13)C]acetate were increased compared to control. Locomotor activity was slightly higher in rats treated wi...Continue Reading

References

Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Jul 1, 1996·Schizophrenia Research·N B FarberJ W Olney
Sep 23, 1997·Glia·U SonnewaldA Schousboe
Jan 28, 1998·Critical Reviews in Neurobiology·C A Tamminga
Feb 5, 2000·Stroke; a Journal of Cerebral Circulation·S M DavisJ Norris
Feb 11, 2000·Annals of the New York Academy of Sciences·M R BullockS A Williams
May 23, 2001·Progress in Neurobiology·N C Danbolt
Sep 5, 2001·The American Journal of Psychiatry·D C Goff, J T Coyle
Jan 23, 2002·Molecular Psychiatry·N B FarberC Heinkel
Jul 12, 2002·Journal of Neural Transmission·S Heckers, C Konradi
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cecilia Flores, Joseph T Coyle
Sep 2, 2003·NeuroImage·L HarrisonK Friston
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Jul 23, 2005·Anesthesia and Analgesia·Sabine Himmelseher, Marcel E Durieux
Jul 28, 2005·Journal of Neurochemistry·Eiliv BrennerUrsula Sonnewald
Jan 6, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel KondziellaUrsula Sonnewald

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Citations

Nov 23, 2010·European Archives of Psychiatry and Clinical Neuroscience·Daniel Martins-de-SouzaChristoph W Turck
Jan 25, 2016·Psychiatry Research. Neuroimaging·Lauren KostenSteven Staelens
Apr 12, 2012·Behavioural Brain Research·Sven AkkermanJos Prickaerts
Dec 5, 2006·Neurotoxicology·Colin L Willis, David E Ray
Aug 5, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jae Chun SongYoung Hoon Kim
Mar 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Birsen OzyurtMustafa Sarsilmaz
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Urs MeyerJoram Feldon
Nov 18, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elvar M EyjolfssonUrsula Sonnewald
Nov 24, 2011·Experimental Neurobiology·Taehwan LeeYunhee Kim Kwon
Aug 17, 2019·Frontiers in Molecular Neuroscience·Gloria Lee, Yi Zhou
Feb 17, 2007·Journal of Neuroscience Research·Eiliv BrennerAstrid Nehlig
May 4, 2021·Frontiers in Pharmacology·Sarah BeggiatoLuca Ferraro

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