Repeated injections of human umbilical cord blood-derived mesenchymal stem cells significantly promotes functional recovery in rabbits with spinal cord injury of two noncontinuous segments

Stem Cell Research & Therapy
Chaohua YangQing Wang

Abstract

Spinal cord injuries (SCIs) are sustained by an increasing number of patients each year worldwide. The treatment of SCIs has long been a hard nut to crack for doctors around the world. Mesenchymal stem cells (MSCs) have shown benefits for the repair of SCI and recovery of function. Our present study aims to investigate the effects of intravenously infused human umbilical cord blood-derived MSCs (hUCB-MSCs) on functional recovery after subacute spinal cord compression injury of two noncontinuous segments. In addition, we compared the effects of single infusion and repeated intravenous (i.v.) injections on the recovery of spinal cord function. A total of 43 adult rabbits were randomly divided into four groups: control, single injection (SI), repeated injection at a 3-day (3RI) or repeated injection at a 7-day interval (7RI) groups. Non-immunosuppressed rabbits in the transplantation groups were infused with either a single complete dose or three divided doses of 2 × 106 hUCB-MSCs (3-day or 7-day intervals) on the first day post decompression. Behavioural scores and somatosensory evoked potentials (SEPs) were used to evaluate hindlimb functional recovery. The survival and differentiation of the transplanted human cells and the act...Continue Reading

References

Mar 11, 2003·Critical Care Medicine·Lawrence R RobinsonHenry L Lew
Jun 20, 2003·Spinal Cord·O N Hausmann
Nov 15, 2005·Neurosurgery·Roberto PalliniEugenio Parati
Dec 21, 2006·Cell Transplantation·Rishi D S Nandoe TewarieMartin Oudega
Mar 23, 2007·Journal of Neurotrauma·Venkata Ramesh DasariDzung H Dinh
Jul 28, 2009·Neurobiology of Disease·Krishna Kumar VeeravalliJasti S Rao
Aug 28, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wenbin LiaoZhong Chao Han
Oct 3, 2009·Neurosurgical Focus·Andres A GonzalezPatrick C Hsieh
Nov 19, 2010·Regenerative Medicine·Nanette JoyceJan A Nolta
Nov 27, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martin M MortazaviVolker K H Sonntag
Feb 19, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yong HuKeith Dip-Kei Luk
Apr 12, 2011·Current Stem Cell Research & Therapy·Joaquim HernándezXavier Navarro
May 18, 2011·The International Journal of Neuroscience·Miyeoun SongByung-Woo Yoon
May 25, 2011·World Journal of Stem Cells·Ju-Yeon KimJong Wook Chang
Jun 7, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rebecca M HaslerFiona Lecky
Oct 20, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masahito KawaboriNagara Tamaki
Dec 26, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Susan H MorrisDouglas D Rasmusson

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Citations

Jun 5, 2019·International Journal of Molecular Sciences·Fabio CofanoDiego Garbossa
Sep 13, 2019·Current Stem Cell Research & Therapy·Jinxuan RenLina Yu
Dec 12, 2018·Neural Regeneration Research·Yana O MukhamedshinaAlbert A Rizvanov
Mar 13, 2021·Stem Cell Research & Therapy·Desheng KongHuixian Cui
Nov 10, 2021·European Journal of Clinical Investigation·Catarina Oliveira Miranda

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Datasets Mentioned

BETA
AB5804
AB5991

Methods Mentioned

BETA
density gradient centrifugation
xenografting

Software Mentioned

ImageJ
SPSS
CellQuest

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