Repeated intracerebroventricular forskolin administration enhances behavioral sensitization to cocaine

Behavioural Brain Research
Joseph A SchroederEllen M Unterwald

Abstract

Repeated cocaine exposure produces behavioral sensitization expressed as an increased locomotor response to subsequent drug administration. Chronic cocaine administration also results in increased activity of adenylyl cyclase and cyclic-AMP (cAMP) dependent protein kinase (PKA) in the nucleus accumbens. To investigate the relationship between cocaine-induced behavioral sensitization and cAMP signaling, the present study examined the effect of forskolin, a direct adenylyl cyclase activator, on cocaine-induced hyperlocomotion and behavioral sensitization to cocaine. Rats were given intracerebroventricular (i.c.v.) injections of a water soluble form of forskolin (7DMB-forskolin) or vehicle 10 min prior to intraperitoneal (i.p.) cocaine or saline administration on 7 consecutive days. Acute or chronic forskolin alone had no effect on locomotor activity at the doses tested. On days 1 and 2, the activity of rats that received i.c.v. forskolin paired with cocaine was not significantly different from rats that received i.c.v. injections of vehicle co-administered with cocaine. By the third day of forskolin/cocaine co-administration, rats displayed enhanced cocaine-induced hyperlocomotor activity compared to rats that received cocaine al...Continue Reading

References

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Citations

Oct 26, 2006·Behavior Genetics·Colin N HaileTherese A Kosten
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Derek P DiRoccoDaniel R Storm
Nov 11, 2008·Annals of the New York Academy of Sciences·Anna M Lee, Robert O Messing
Oct 29, 2005·Pharmacology, Biochemistry, and Behavior·Osnat Ben-ShaharAaron Ettenberg
Mar 22, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·W GoutierA C McCreary

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