Repeated intravitreal high-dosage injections of triamcinolone acetonide for diffuse diabetic macular edema

Ophthalmology
Jost B JonasGangolf Sauder

Abstract

To report the results of repeated intravitreal injections of triamcinolone acetonide for treatment of diffuse diabetic macular edema. Retrospective interventional comparative study. The investigation included a study group (the responders) of 19 patients (22 eyes) with diffuse diabetic macular edema, who showed an improvement in visual acuity after an intravitreal injection of approximately 20 mg triamcinolone acetonide, and who received a second intravitreal injection 10.0+/-3.8 months after the first injection. A control group consisted of 31 patients with diffuse diabetic macular edema without treatment during follow-up. Intravitreal injection of approximately 20 mg triamcinolone acetonide. Visual acuity and intraocular pressure. Follow-up after the second injection was 9.1+/-4.9 months. Four patients received a third injection at 9.7+/-3.7 months after the second injection, with a follow-up after the third injection that was at 7.9+/-11.5 months. After the second and third injections, visual acuity increased significantly (P = 0.002 and P = 0.068, respectively) by 1.8+/-2.1 and 4.0+/-2.6 Snellen lines, respectively. Eleven eyes (50%) showed an improvement in visual acuity by at least 2 Snellen lines after the second injecti...Continue Reading

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Citations

Jan 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hans HoeraufClaudia Weiss
Nov 28, 2007·Retina·Iryna A FalkensteinWilliam R Freeman
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