Repeated ketamine administration redeems the time lag for citalopram's antidepressant-like effects

European Psychiatry : the Journal of the Association of European Psychiatrists
G-F ZhangZ-Q Zhou

Abstract

Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent and consecutive administrations of ketamine on chronic unpredictable mild stress (CUMS) rats, and to determine whether ketamine can redeem the time lag for treatment response of classic antidepressants. The behavioral responses were assessed by the sucrose preference test, forced swimming test, and open field test. In the first stage of experiments, all the four treatment regimens of ketamine (10mg/kg ip, once daily for 3 or 7 consecutive days, or once every 7 or 3 days, in a total 21 days) showed robust antidepressant-like effects, with no significant influence on locomotor activity and stereotype behavior in the CUMS rats. The intermittent administration regimens produced longer antidepressant-like effects than the consecutive administration regimens and the administration every 7 days presented similar antidepressant-like effects with less adminis...Continue Reading

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Citations

Sep 30, 2016·Forensic Science International : Synergy·Eunyoung HanHeesun Chung
Mar 24, 2020·Psychiatry Investigation·Feyza AricioğluTijen Utkan
Sep 27, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Carlos A Zarate, Mark J Niciu
Oct 19, 2017·The International Journal of Neuropsychopharmacology·Marie SpiesRupert Lanzenberger
Mar 7, 2021·The International Journal of Neuropsychopharmacology·Chidiebere M IroPierre Blier
May 29, 2021·Frontiers in Psychiatry·Ridge G WestonBrendon O Watson

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