PMID: 3768705Sep 24, 1986Paper

Repeated low doses of morphine induce a rapid tolerance in arthritic rats but a potentiation of opiate analgesia in normal animals

Brain Research
V KayserG Guilbaud

Abstract

The effect of repeated low doses of morphine (0.3-3 mg/kg s.c., twice daily for 4 days) on subsequent sensitivity to the antinociceptive effect of morphine was tested in arthritic and normal rats. Chronic morphine induces tolerance in arthritic rats. This tolerance develops rapidly since it is clearly present after one day of treatment. By contrast, in normal animals similarly treated, a potentiation of morphine analgesia was observed.

References

Jan 1, 1976·Annals of the New York Academy of Sciences·J Cochin, B E Mushlin
Jun 1, 1968·British Journal of Pharmacology and Chemotherapy·B M CoxO H Osman

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Citations

Oct 29, 1993·Neuroscience Letters·A L Vaccarino, L C Couret
Mar 30, 1999·Life Sciences·J Y LiJ C Chen
Oct 29, 2013·The Journal of Pain : Official Journal of the American Pain Society·Melissa L MehalickMichael M Morgan
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Sep 14, 2004·Journal of Neurobiology·Michael H OssipovFrank Porreca

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