Repeated measurement: sensitive tests for experiments with few animals

Journal of Animal Science
J L Gill

Abstract

Animal scientists who conduct experiments involving repeated measurements of animals often are frustrated by low statistical power of tests for comparisons of treatment means. In many cases, low power of the traditional tests simply is the consequence of low replication (few animals per treatment) that was forced by cost or complexity of experimental technique. A method is given for comparing treatments in a way that permits sensitive tests (via partition of the treatment X period interaction), often when the number of animals per treatment is not more than five or six. Modifications for the procedure are given for the case of heterogeneous variances and covariances. An example from mammary physiology is used to illustrate the procedure and to compare it with standard methods of analysis.

Citations

Jul 1, 1994·Journal of Dairy Science·C R SimmonsH A Tucker
May 1, 1992·Journal of Pineal Research·B A BuchananH A Tucker
Apr 1, 1994·The British Journal of Nutrition·D O FreudenbergerJ M Suttie
Apr 1, 1996·Journal of Dairy Science·D W LaCountJ K Drackley
Oct 24, 2007·The Journal of Nutrition·Koji YasudaXin Gen Lei
Jun 1, 1991·Archiv für Tierernährung·U SteinruckF X Roth
Feb 1, 1996·Journal of Dairy Science·D W LaCountJ K Drackley
Sep 1, 1989·Digestive Diseases and Sciences·R E HollandK R Refsal
Mar 1, 1994·Journal of Dairy Science·B D GarthwaiteE H Jaster
May 27, 2006·Theriogenology·B A BallI Dobrinski
May 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·X G LeiK R Roneker
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·K D ZimmermanH Heatwole

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