Repeated-measures analysis of the National Institute of Neurological Disorders and Stroke rt-PA stroke trial

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Wuwei FengAdnan I Qureshi

Abstract

Previous analyses, including the National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stoke Trial, have assessed the clinical treatment efficacy only at single study point, but did not assess efficacy using outcomes collected at multiple time points and incorporate within-patient correlation. The data from the NINDS rt-PA Stroke Trial was analyzed with repeated-measures analysis with generalized estimating equations (GEE) approach using dichotomized outcomes (modified Rankin Scale [mRS], National Institutes of Health Stroke Scale [NIHSS], Barthel Index [BI], and Glasgow Outcome Scale [GOS]). The results were compared with data from previous analyses. All of the outcome variables at different time points were significantly correlated. rt-PA was superior to placebo overall and at specific time points individually. The overall odds of having minimal or no disability (mRS score 0 or 1) for patients treated with rt-PA was higher than those treated with placebo (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.5-3.0). The ORs were 2.3 (95% CI, 1.5-3.4) times higher at 3 months, 1.9 (95% CI, 1.3-2.8) times higher at 6 months, and 2.0 (95% CI, 1.3-2.9) times higher at 12 months. A similar treatment effect also was...Continue Reading

References

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Citations

Oct 24, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Fraser C GoldieUNKNOWN VISTA Collaboration
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Joanna M WardlawGregory J del Zoppo
Jun 24, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·R Rodney Howell, Stephan Zuchner
Nov 20, 2014·Pediatric Radiology·Ali GholipourSimon K Warfield
Apr 3, 2012·Journal of Occupational Rehabilitation·Silje Endresen RemeGlorian Sorensen
Nov 3, 2017·Journal of Pediatric Psychology·Christina E HolbeinKevin A Hommel
Aug 8, 2015·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Nancy S RedekerPatricia Grady
Jan 29, 2019·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Stefania PaganizzaCristina Canova

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