PMID: 9537680Apr 16, 1998Paper

Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum

Psychopharmacology
C A CrawfordJ B Watson

Abstract

The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the occurrence of behavioral sensitization. In two experiments, adult rats were injected (i.p.) on 5 consecutive pre-exposure days with saline or MPH (5, 10, 15, or 20 mg/kg). Sensitization was tested after a single abstinence day, with rats receiving a challenge injection of MPH prior to either a 40- or 150-min testing session (additional control groups received saline on the test day). Immediately after the 40-min testing session, rats were killed and tissue from the dorsal striatum was dissected for later analysis of PKA and adenylyl cyclase activity. Results showed that repeated MPH treatment sensitized the stereotyped sniffing, but not the locomotor activity, of adult rats. PKA activity was significantly depressed in rats treated with MPH (10 or 20 mg/kg) during both the pre-exposure and test day phases. DA-stimulated adenylyl cyclase activity was reduced after chronic MPH treatment, while basal adenylyl cyclase ...Continue Reading

Citations

Aug 30, 2001·European Journal of Pharmacology·P YangN Dafny
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·C A CrawfordS A McDougall
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Susan Schenk, Sari Izenwasser
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Edgar Appenrodt, Helmut Schwarzberg
Jan 8, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Motoyo Yano, Heinz Steiner
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Jan 24, 2014·American Journal on Intellectual and Developmental Disabilities·Nicole M Russo-PonsaranElizabeth Berry-Kravis
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