Repeated nicotine exposure during adolescence alters reward-related learning in male and female rats

Behavioural Brain Research
Stacey L QuickJane R Taylor

Abstract

Repeated nicotine exposure causes neuroadaptations in limbic cortico-striatal circuits involved in learning and motivation. Such alterations are relevant to addiction because they are suggested to mediate the ability of smoking-associated stimuli to control behavior and to enhance nicotine-seeking and -taking behaviors. Female smokers report higher cue reactivity relative to their male counter parts, yet little is known about putative gender-specific effects of adolescent nicotine exposure on reward-related learning. Prior repeated nicotine exposure in adult male rats enhances Pavlovian approach behavior and conditioned reinforcement. Given that smoking is typically initiated during adolescence, here we assessed the extent to which adolescent nicotine exposure impacts Pavlovian approach and conditioned reinforcement in male and female rats. Rats were injected with nicotine on postnatal days 31-45 prior to training on Pavlovian approach behavior starting on day 51. They were trained to associate a conditioned stimulus (CS), illumination of a magazine light, and tone, with an unconditioned stimulus (US), the delivery of water, for 10-daily sessions, and then were tested on the acquisition of responding with conditioned reinforcem...Continue Reading

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Citations

Jan 19, 2016·Behavioural Brain Research·Heidi C MeyerDavid J Bucci
Dec 3, 2014·Neurotoxicology and Teratology·Amy K GoodwinSherry A Ferguson
May 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marcia SpoelderJeremy J Clark
Jun 8, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·William M Perry, Susanne L T Cappendijk
Oct 25, 2017·Behavioural Pharmacology·Lindsay P SchwartzAlan Silberberg
Jan 29, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Cali A Calarco, Marina R Picciotto

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