PMID: 8963396Dec 1, 1995Paper

Repeated piezoelectric lithotripsy for gallstones with and without ursodeoxycholic acid dissolution: a multicenter study

Journal of Gastroenterology
Y TsuchiyaY Kawai

Abstract

The use of bile acid dissolution therapy in extracorporeal shockwave lithotripsy of gallstones, remains controversial. Our study examined whether chemolitholysis after sufficient disintegration enhanced stone clearance within 6 months of the first lithotripsy. A total of 143 patients who developed one to three radiolucent stones measuring < or = 30 mm in diameter were randomly separated into two treatment groups: 47% were given lithotripsy alone, and 53% lithotripsy plus ursodeoxycholic acid (UDCA). Repeated piezoelectric lithotripsy was given, with no limit on the total number of treatment sessions, to pulverize or disintegrate stones into fragments < 3 mm. Stones were disintegrated in 97% of all patients, and the fragments were < or = 2 mm in 50% of these patients. According to an intention-to-treat analysis, 52% in the lithotripsy alone group and 58% in the UDCA group were free of stones 6 months after the first lithotripsy (P = 0.61). Of the patients with fragments < or = 2 mm, 71% in the former and 86% in the latter group were free of stones 6 months after the first lithotripsy, with no significant difference between the groups. Biliary pain occurred in 25% of all patients, including 3 with acute cholecystitis. We conclude...Continue Reading

References

Mar 1, 1992·Gastroenterology·M SackmannG Paumgartner
Feb 15, 1991·Annals of Internal Medicine·M SackmannG Paumgartner
Dec 1, 1990·Radiology·J S FacheH J Burhenne
Jul 15, 1990·Annals of Internal Medicine·M B AlbertR Gicking
Feb 18, 1988·The New England Journal of Medicine·M SackmannW Brendel
Mar 27, 1986·The New England Journal of Medicine·T SauerbruchW Brendel
Nov 1, 1994·Journal of Gastroenterology and Hepatology·Y TsuchiyaM Ohto

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Citations

May 11, 2002·The American Journal of Gastroenterology·Atilla Ertan
Apr 14, 2000·Journal of Gastroenterology and Hepatology·E Mulagha, H Fromm
Feb 25, 2006·Scandinavian Journal of Gastroenterology·Luís Carrilho-RibeiroMiguel Carneiro De Moura
Dec 13, 2016·Journal of Gastroenterology·Susumu TazumaTooru Shimosegawa

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