Repeated pneumatic dilations as long-term maintenance therapy for esophageal achalasia

The American Journal of Gastroenterology
Frank ZerbibHervé Lamouliatte

Abstract

In esophageal achalasia, pneumatic dilations (PD) provide short-term and long-term remission rates of 60-90% and 40-50%, respectively. The aim of this study was to evaluate the long-term efficacy of repeated PD as long-term maintenance therapy. From 1992 to 2004, 150 patients with esophageal achalasia treated by PD were included in this retrospective study (78 males, mean age 57 +/- 20 yr). PD were performed until remission was achieved (symptom score < or = 3, each item < 2) and subsequently when symptomatic recurrence occurred. A standardized symptoms questionnaire was sent to patients lost to follow-up. Results are expressed as mean +/- SD. Initial remission was achieved in 137 of 150 (91.3%) patients with 2.67 +/- 1.59 dilations [range 1-12]. Failure and perforation rates were 7.3% (n = 11) and 1.3% (n = 2), respectively. After initial remission, 48 of 137 (35%) patients had recurrent symptoms; the probability to be in remission at 5 and 10 yr was 67% and 50%, respectively. At the end of follow-up (45 +/- 38 months, ext. 2-144) 108 of 137 (78.8%) patients were in remission. Among 112 patients whose symptoms could be treated by repeated PD (per protocol analysis), 108 (96.4%) were in remission (3.5 +/- 2.1 PD, ext. 2-12). In...Continue Reading

References

Dec 1, 1992·Gastroenterology·V F EckardtG Bernhard
Nov 1, 1983·Gut·G Vantrappen, J Janssens
Aug 26, 1998·Journal of Clinical Gastroenterology·M F Vaezi, J E Richter
Aug 26, 1998·JAMA : the Journal of the American Medical Association·A E Spiess, P J Kahrilas
Sep 30, 1998·Digestive Diseases and Sciences·P O KatzD O Castell
Dec 3, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M G PattiL W Way
Mar 18, 1999·Digestive Diseases and Sciences·P AlonsoJ L Vázquez-Iglesias
Dec 22, 1999·The American Journal of Gastroenterology·J KolbasnikG Tougas
Apr 16, 2002·European Journal of Gastroenterology & Hepatology·Natalia ZárateJuan-Ramón Malagelada
Jul 4, 2002·The American Journal of Gastroenterology·R L WestG E Boeckxstaens
Mar 10, 2004·American Journal of Surgery·Mark BloomstonAlexander S Rosemurgy
Mar 17, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mustafa A ArainTom R DeMeester
Apr 13, 2004·Annals of Surgery·Ines GockelVolker F Eckardt
Jan 26, 2005·The American Journal of Gastroenterology·Georgios KaramanolisApostolos Mantides

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Citations

May 13, 2011·The New England Journal of Medicine·Guy E BoeckxstaensUNKNOWN European Achalasia Trial Investigators
Mar 19, 2013·Therapeutic Advances in Gastroenterology·Stavros N StavropoulosJames H Grendell
Jun 23, 2011·Clinical and Experimental Gastroenterology·Luca DugheraFabio Cisarò
Aug 26, 2009·World Journal of Gastroenterology : WJG·Alexander J Eckardt, Volker F Eckardt
Oct 28, 2009·World Journal of Gastroenterology : WJG·Javad MikaeliReza Malekzadeh
Jan 27, 2010·World Journal of Gastroenterology : WJG·Seng-Kee ChuahChi-Sin Changchien
Oct 27, 2010·World Journal of Gastroenterology : WJG·Ying-Sheng ChengChun-Gen Wu
Sep 12, 2013·World Journal of Gastroenterology : WJG·Seng-Kee ChuahKeng-Liang Wu
Aug 4, 2010·Journal of Neurogastroenterology and Motility·Joel E Richter
Jun 2, 2011·Seminars in Interventional Radiology·Kevin J BlountEduard E de Lange
Sep 5, 2006·Alimentary Pharmacology & Therapeutics·J M Lake, R K H Wong
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Joel E Richter
Nov 24, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X TangB Jiang
Dec 8, 2016·Alimentary Pharmacology & Therapeutics·T SawasD A Katzka
Mar 12, 2016·United European Gastroenterology Journal·Claudia Krieger-GrübelJan Borovicka
Nov 16, 2017·Journal of Gastroenterology and Hepatology·Michaela MüllerInes Gockel
May 17, 2018·Annals of the New York Academy of Sciences·Valter Nilton Felix
Sep 18, 2014·World Journal of Gastrointestinal Endoscopy·Salvatore ToloneLudovico Docimo
Aug 21, 2013·World Journal of Gastrointestinal Endoscopy·Michaela MüllerTill Wehrmann
Sep 18, 2013·World Journal of Gastrointestinal Endoscopy·David FriedelStavros N Stavropoulos
Mar 6, 2013·The American Journal of Gastroenterology·Vivek KumbhariIan J Cook
Apr 28, 2011·Nature Reviews. Gastroenterology & Hepatology·Alexander J Eckardt, Volker F Eckardt
Jul 24, 2013·The American Journal of Gastroenterology·Michael F VaeziMarcelo F Vela
Oct 13, 2006·The American Journal of Gastroenterology·Radu TutuianPhilip O Katz
Sep 26, 2012·The American Journal of Gastroenterology·W O RohofG E Boeckxstaens
May 5, 2007·Surgical Endoscopy·Paul J KaranicolasAmiram Gafni
Jun 5, 2007·Current Opinion in Gastroenterology·Hanneke Beaumont, Guy Boeckxstaens
Dec 29, 2015·The Kaohsiung Journal of Medical Sciences·Hsin-Ming WangChi-Sin Changchien
Nov 22, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J A TusetE Medina
Jan 24, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Seng-Kee ChuahChi-Sin Changchien
Jul 9, 2008·Journal of Pediatric Gastroenterology and Nutrition·Licia Pensabene, Samuel Nurko
Nov 19, 2009·Journal of Gastroenterology·Yuriko TanakaChoitsu Sakamoto
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y-D LiJ-G Zhao
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J M HowardJ V Reynolds
Apr 26, 2006·The American Journal of Gastroenterology·Roy K H Wong
Oct 19, 2011·Alimentary Pharmacology & Therapeutics·T VanuytselJ Tack
Nov 3, 2011·Surgical Endoscopy·Dimitrios StefanidisUNKNOWN Society of American Gastrointestinal and Endoscopic Surgeons
Mar 8, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·G E BoeckxstaensG Zaninotto
Apr 18, 2012·Current Opinion in Gastroenterology·Wout O Rohof, Guy E Boeckxstaens

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