Repeated post- or presession cocaine administration: roles of dose and fixed-ratio schedule

Journal of the Experimental Analysis of Behavior
Jonathan W Pinkston, Marc N Branch

Abstract

Effects of repeated administration of cocaine to animals behaving under operant contingencies have depended on when the drug is given. Moderate doses given presession have generally led to a decrease in the drug's effect, an outcome usually referred to as tolerance. When these same doses have been given after sessions, the usual result has been no change or an increase in the drug's effects, with the latter usually referred to as sensitization. In the present study, repeated postsession administration of a relatively small dose of cocaine (3.0 or 5.6 mg/kg) to pigeons responding under a multiple fixed-ratio 5, fixed-ratio 100 schedule of food presentation generally resulted in tolerance to the rate-decreasing effects of the drug. When the same dose was given before sessions, little additional tolerance was observed, although some subjects showed further tolerance in the small-ratio component. A regimen of repeated postsession injection of larger (10.0-23.0 mg/kg) doses suppressed key pecking during the session; responding resumed following discontinuation of postsession administrations. Effects of postsession administration of cocaine, therefore, depended on the dose, with smaller doses leading to tolerance and larger ones to s...Continue Reading

References

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Citations

Aug 6, 2009·Experimental and Clinical Psychopharmacology·Jonathan W PinkstonR J Lamb
Sep 9, 2010·Behavioural Pharmacology·Matthew T WeaverMarc N Branch
Oct 5, 2010·Journal of the Experimental Analysis of Behavior·Tracy G TaylorRonald E See
Jun 2, 2010·Journal of the Experimental Analysis of Behavior·Jin Ho Yoon, Marc N Branch
Sep 11, 2013·Journal of the Experimental Analysis of Behavior·Vanessa Minervini, Marc N Branch

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