Repeated rat exposure inhibits the circadian activity patterns of C57BL/6J mice in the home cage

Behavioural Brain Research
S DalmMelly S Oitzl

Abstract

Exposing male C57BL/6J mice repeatedly, in an unpredictable and uncontrollable fashion to rats, alters their cognitive performance and the neuroendocrine stress response, weeks to months after the rat stress. Continuous observation of the behavioural activity of male C57BL/6J mice in their home cage before (baseline) and after rat exposure could reveal if repeated rat exposure leads to changes in circadian activity patterns, which is a key feature of chronic stress and stress-related disorders in humans. Rat stress (1) decreased exploratory and foraging activity as characterized by increased time spent in the shelter and less time in the open area; (2) reduced sucrose consumption and inhibited the development of sucrose preference, suggesting changes in the reward system and (3) the exploration pattern in a novel environment included more behavioural perseverations, but no change in general locomotor activity. Comparison to baseline activity pattern, i.e., before any intervention, revealed that already the control procedure to rat exposure (spending the same amount of time in another cage) disrupted the organization of behavioural activity patterns, albeit to a different and lesser degree than observed in rat stressed mice. Whi...Continue Reading

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Citations

Mar 31, 2012·Medicine and Science in Sports and Exercise·Gretchen Wolff, Karyn A Esser
Jun 12, 2014·Translational Stroke Research·Allison KunzeKyra Becker
Oct 7, 2009·Hormones and Behavior·Vanessa Cristiane Santana AmaralRicardo Luiz Nunes-de-Souza
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Melly S OitzlE Ronald de Kloet
Jan 12, 2017·Chemical Senses·Ying-Juan LiuJian-Xu Zhang
Jul 16, 2020·Animals : an Open Access Journal From MDPI·Rachel KinsmanJane Murray

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