Repeated Sport-Related Concussion Shows Only Minimal White Matter Differences Many Years After Playing High School Football

Journal of the International Neuropsychological Society : JINS
Douglas P TerryL Stephen Miller

Abstract

Multiple concussions sustained in youth sport may be associated with later-life brain changes and worse cognitive outcomes. We examined the association between two or more concussions during high school football and later-life white matter (WM) microstructure (i.e., 22-47 years following football retirement) using diffusion tensor imaging (DTI). Forty former high school football players aged 40-65 who received 2+ concussions during high school football (N = 20), or denied concussive events (N = 20) were recruited. Participants underwent neurocognitive testing and DTI scanning. Groups did not statistically differ on age, education, or estimated pre-morbid intelligence. Tract-based Spatial Statistics (TBSS) correcting for Family-Wise Error (FWE)(p < .05) did not yield differences between groups at the whole-brain level. Region of interest analyses showed higher mean diffusivity (MD) in the anterior limb of the internal capsule (ALIC) in the concussed group compared to the non-concussed former players. More liberal analyses (i.e., p < .001, uncorrected for multiple comparisons, ≥8 voxels) also revealed that former players endorsing 2+ concussions had higher MD in the ALIC. Analyses that covaried for age did not reveal differences ...Continue Reading

References

Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Apr 16, 2004·Journal of Rehabilitation Medicine·J David CassidyUNKNOWN WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury

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Citations

Mar 19, 2020·Journal of the International Neuropsychological Society : JINS·Maya N SohnBrian L Brooks
Mar 23, 2021·Frontiers in Behavioral Neuroscience·Taylor A McCorkleRamesh Raghupathi

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