Repeated stress-induced stimulation of catecholamine response is not followed by altered immune cell redistribution

Annals of the New York Academy of Sciences
Richard ImrichMilan Vigas

Abstract

Stress response is considered an important factor in the modulation of immune function. Neuroendocrine hormones, including catecholamines, affect the process of immune cell redistribution, important for cell-mediated immunity. This longitudinal investigation was aimed at evaluating the effect of repeated stress-induced elevation of catecholamines on immune cell redistribution and expression of adhesive molecules. We assessed the responses of epinephrine (EPI), norepinephrine (NE), cortisol, changes in lymphocytes subpopulations, and percentages of CD11a+, CD11b+, and CD62L+ lymphocytes to a 20-min treadmill exercise of an intensity equal to 80% of the individual's Vo(2)max. The exercise was performed before and after 6 weeks of endurance training consisting of a 1-h run 4 times a week (ET) and after 5 days of bed rest (HDBR) in 10 healthy males. We did not observe any significant changes in the basal levels of EPI, NE, and cortisol in the plasma, nor in the immune parameters after ET and HDBR. The exercise test led to a significant (P <.001) elevation of EPI and NE levels after both ET and HDBR, a significant elevation (P <.01) of cortisol after HDBR, an increase in the absolute numbers of leukocytes, granulocytes, monocytes, C...Continue Reading

References

Jun 1, 1988·Scandinavian Journal of Immunology·B K PedersenK Klarlund
Mar 1, 1997·International Journal of Sports Medicine·B K PedersenM Zacho
Mar 1, 1997·International Journal of Sports Medicine·S Nehlsen-CannarellaR Thorpe
May 1, 1997·Journal of Applied Physiology·D C Nieman
Jun 16, 2001·Journal of Applied Physiology·J SmorawińskiJ E Greenleaf

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Citations

Jun 22, 2006·Journal of Occupational Health·Manas R RayTwisha Lahiri
Sep 28, 2018·Current Cardiology Reports·Sarah M Schumacher, Sathyamangla V Naga Prasad

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