Repeated stressor exposure enhances contextual fear memory in a beta-adrenergic receptor-dependent process and increases impulsivity in a non-beta receptor-dependent fashion

Physiology & Behavior
Robert M Camp, John D Johnson

Abstract

Memory formation is promoted by stress via the release of norepinephrine and stimulation of beta-adrenergic receptors (β-ARs). Previous data demonstrate that repeated stressor exposure increases norepinephrine turnover and β-AR signaling within the amygdala, which led to the hypothesis that some stress-induced behavioral changes are likely due to facilitated associative learning. To test this, Fischer rats were exposed to chronic mild stress for four days. On day 5, subjects (including non-stressed controls) were injected with the beta-blocker propranolol or vehicle prior to conditioning in an operant box (animals receive two mild foot shocks) or passive avoidance apparatus (animals received a foot shock upon entry into the dark chamber). Twenty-four hours later, subjects were returned to the operant box for measurement of freezing or returned to the passive avoidance apparatus for measurement of latency to enter the dark chamber. Subjects were also tested in an open field to assess context-independent anxiety-like behavior. Animals exposed to chronic stress showed significantly more freezing behavior in the operant box than did controls, and this exaggerated freezing was blocked by propranolol during the conditioning trial. Th...Continue Reading

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Citations

Mar 15, 2016·Psychoneuroendocrinology·Steven A LowranceJohn D Johnson
Nov 11, 2016·Biomolecules & Therapeutics·Se Jin JeonJong Hoon Ryu
Mar 18, 2016·Physiological Reviews·Ivan IzquierdoJociane C Myskiw
Feb 28, 2018·Brain and Behavior·Rong-Ting ZhuHu Zhao
Jun 10, 2017·Neural Plasticity·Olga BorodovitsynaDaniel Chandler
Feb 7, 2018·Journal of Toxicology and Environmental Health. Part a·Adrieli SachettAnna M Siebel
Jun 11, 2021·Research in Veterinary Science·Odilene de Souza TeixeiraJúlio Otávio Jardim Barcellos

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