Repeated subarachnoid administrations of allogeneic human umbilical cord mesenchymal stem cells for spinal cord injury: a phase 1/2 pilot study.

Cytotherapy
Yang YangLi-Min Rong

Abstract

Stem cell transplantation is a potential treatment for intractable spinal cord injury (SCI), and allogeneic human umbilical cord mesenchymal stem cells (hUC-MSCs) are a promising candidate because of the advantages of immune privilege, paracrine effect, immunomodulatory function, convenient collection procedure and little ethical concern, and there is an urgent need to develop a safe and effective protocol regarding their clinical application. A prospective, single-center, single-arm study in which subjects received four subarachnoid transplantations of hUC-MSCs (1 × 106 cells/kg) monthly and were seen in follow-up four times (1, 3, 6 and 12 months after final administration) was conducted. At each scheduled time point, safety and efficacy indicators were collected and analyzed accordingly. Adverse events (AEs) were used as a safety indicator. American Spinal Injury Association (ASIA) and SCI Functional Rating Scale of the International Association of Neurorestoratology (IANR-SCIFRS) total scores at the fourth follow-up were determined as primary efficacy outcomes, whereas these two indicators at the remaining time points as well as scores of pinprick, light touch, motor and sphincter, muscle spasticity and spasm, autonomic sys...Continue Reading

References

Jun 8, 1989·The New England Journal of Medicine·R D PennJ S Kroin
Feb 1, 1987·Physical Therapy·R W Bohannon, M B Smith
May 4, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jeffrey L SpeesDarwin J Prockop
Dec 14, 2005·Spinal Cord·K KroghS Laurberg
Jan 1, 2012·Topics in Spinal Cord Injury Rehabilitation·Stephen BurnsWilliam Waring
Jul 2, 2015·Molecular Medicine Reports·Shengying LiMingli Ji
Mar 15, 2016·Cytotherapy·Humayoon Shafique SattiSalman Akbar Malik
Jun 18, 2016·Cytotherapy·Jesús VaqueroUNKNOWN Neurological Cell Therapy Group
Feb 23, 2017·Journal of Neurotrauma·Kim D AndersonAllan D Levi
Mar 30, 2017·Neurosurgery·Christopher S AhujaMichael G Fehlings
May 13, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pravin Shende, Muna Subedi
May 23, 2018·Cytotherapy·Jesús VaqueroUNKNOWN Neurological Cell Therapy Group From Puerta De Hierro-Majadahonda Hospital
Jun 2, 2018·Cytotherapy·Jesús VaqueroUNKNOWN Neurological Cell Therapy Group from Puerta de Hierro-Majadahonda Hospital
Nov 2, 2018·Nature·Fabien B WagnerGrégoire Courtine
Jan 23, 2020·International Journal of Molecular Sciences·Serena SilvestroEmanuela Mazzon

❮ Previous
Next ❯

Citations

Apr 24, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Songyu LiuJunzhi Lin
Jul 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuan TianKazuichi Sakamoto
Oct 16, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shehzahdi Shebbrin MoonshiHang Thu Ta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.