PMID: 9651823Jul 4, 1998Paper

Repeated subcutaneous injection of staphylococcal enterotoxin B-stimulated lymphocytes retains epidermal thickness of psoriatic skin-graft onto severe combined immunodeficient mice

Journal of Dermatological Science
T YamamotoK Nishioka

Abstract

Several approaches have recently been carried out to attempt to establish a mouse transplantation model of psoriasis. To study the effects of superantigen-driven peripheral blood mononuclear cells (PBMCs) on the persistence of psoriasiform epidermis and cytokine gene expression of the grafted psoriatic skin, staphylococcal enterotoxin B (SEB)-stimulated PBMCs (SEB-PBMCs) from psoriatic patients were subcutaneously injected once or repeatedly under the grafted full-thickness involved psoriatic skin onto severe combined immunodeficient (SCID) mice. After 5 weeks, the persistence of a psoriasiform epidermis was most distinct in mice with repeated injection of SEB-PBMCs. E-selectin expression was observed on endothelial cells in the upper dermis in mice with repeated injection of both SEB-stimulated and unstimulated PBMCs, while mice with single injection of unstimulated or SEB-PBMCs did not show positive staining. Both interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma) mRNA were detected after 5 weeks, only in mice with repeated injection of SEB-PBMCs. It is concluded that continuous supply of the activated PBMCs may help the persistence of psoriasiform architecture more clearly, and that this transplantation mouse mo...Continue Reading

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Citations

Aug 2, 2003·Journal of the American Academy of Dermatology·Stephanie L Mehlis, Kenneth B Gordon
Mar 8, 2002·Clinical and Experimental Immunology·A KoreckA Dobozy
Feb 15, 2005·Annals of the Rheumatic Diseases·L S WinterfieldA Gottlieb
Jul 25, 2006·Expert Opinion on Investigational Drugs·Daniel BockGerhard Wolff
Jul 5, 2005·Expert Opinion on Investigational Drugs·B J Nickoloff
Jun 1, 2006·Expert Opinion on Drug Discovery·Frederik H IgneyThomas M Zollner
Oct 13, 2006·Current Opinion in Infectious Diseases·A D SawitzkeB C Cole
Jan 27, 2019·Experimental and Therapeutic Medicine·Mihaela SurcelCornel Ursaciuc
Dec 15, 2005·Advances in Dermatology·Ruby Ghadially

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