PMID: 8985901Dec 1, 1996Paper

Repeated tetanic stimulation in piriform cortex in vitro: epileptogenesis and pharmacology

Journal of Neurophysiology
M R Pelletier, P L Carlen

Abstract

1. Focal cortical epilepsy was investigated by applying tetanic stimulation repeatedly (100 Hz. 2 s in duration, once every 10 min, 10 episodes) to layer III association fibers in rat piriform cortex slices and recording both extracellular and intracellular responses from the endopiriform nucleus. To promote excitability, piriform slices were incubated in artificial cerebrospinal fluid (ACSF) containing 0.9 mM Mg2+ and 5 mM K+, at an initial temperature of 10-12 degrees C, which was allowed to warm passively to room temperature. 2. Responses recorded extracellularly in the endopiriform nucleus consisted of two types: weak stimulation evoked an early-occurring, small-amplitude, negatively deflecting potential; strong stimulation evoked a more complex response comprising both an early potential of maximal amplitude and a later-occurring epileptiform potential of greater amplitude and longer duration. Late-occurring epileptiform potentials were not observed in slices incubated in ACSF at room temperature. 3. Both the early potential and the late-occurring epileptiform responses were abolished by the non-N-methyl-D-aspartic acid (non-NMDA) subtype of glutamate receptor blocker, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 10 microM)...Continue Reading

Citations

May 30, 1998·Journal of Neurophysiology·M PostlethwaiteV Libri
Jul 30, 2004·The Journal of Comparative Neurology·Katarzyna MajakAsla Pitkänen
Dec 22, 1999·Journal of Neurophysiology·M Steriade, F Amzica
Jul 17, 2021·Reviews in the Neurosciences·Roger D TraubMiles A Whittington

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