Repeated treatment protocols for melasma and acquired dermal melanocytosis

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Kotaro YoshimuraIsao Koshima

Abstract

Melasma and acquired dermal melanocytosis (ADM; acquired bilateral nevus of Ota-like macules) are both seen most commonly symmetrically on the face of women with darker skin and are also known as difficult conditions to treat. Our topical bleaching protocol with 0.1 to 0.4% tretinoin gel and 5% hydroquinone was performed repeatedly (1-3 times) for melasma (n=163), and a combination treatment with topical bleaching and Q-switched ruby (QSR) laser was performed repeatedly (1-3 times) for ADM (n=62). There is a significant correlation between clinical results (clearance of pigmentation) and the number of sessions in both melasma (p=.019) and ADM (p<.0001). The repeated treatment protocol for melasma and ADM showed successful clinical results compared with conventional ones, and they may be applied to other pigment conditions. It may be better that epidermal and dermal pigmentations are treated separately, especially in dark-skinned people who are more likely to suffer postinflammatory hyperpigmentation after inflammation-inducing therapies.

References

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Citations

Jul 31, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Katsujiro SatoKotaro Yoshimura
Mar 3, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rungsima WanitphakdeedechaT Minsue Chen
Apr 16, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kristel D PolderSuzanne Bruce
Aug 12, 2008·Clinics in Dermatology·Xing-Hua GaoHong-Duo Chen
Jan 26, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·R WanitphakdeedechaW Manuskiatti
Sep 17, 2014·Clinical and Experimental Dermatology·X ChenL Chen
May 7, 2010·The Journal of Dermatological Treatment·Kee Suck SuhSang Tae Kim

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