Repeated triamcinolone acetonide injection in the treatment of upper-lid retraction in patients with thyroid-associated ophthalmopathy

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Dongdong XuHui Li

Abstract

To evaluate the efficacy and safety of repeated subconjunctival injections of triamcinolone in the treatment of upper-lid retraction with thyroid-associated ophthalmopathy. Interventional controlled retrospective clinical study. We studied 23 eyes in 15 patients as the nontreatment control group and 35 eyes in 21 patients as the treatment group. In the treatment group, triamcinolone acetonide was subconjunctivally injected into each lid as 4 doses of 20 mg at 1-month intervals. After the treatment, the eyes were divided into 2 groups, response and nonresponse, based on the improvement in margin reflex distance. The eyes of the nontreatment group received no medicine. The eyes were examined regularly. The rate of spontaneous improvement in the nontreatment group was 17.4%. The mean rate of effectiveness was 68.6%. The improvement of upper-lid retraction was 2.31 mm (0 to 7 mm). The margin reflex distance was significantly smaller at 1 month after the initiation of treatment. Mean lid retraction time before treatment was 4.58 months in the response group versus 9.91 months in the nonresponse group. In the eyes presenting upper-lid retraction up to 6 months before treatment was initiated, the response rate was 83.3%. The response ...Continue Reading

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Citations

Feb 13, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shirin Hamed-AzzamDaniel Briscoe
Jan 9, 2013·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zhu-Hua ZhangZheng-Yu Jin
Aug 11, 2017·The British Journal of Ophthalmology·Ana Beatriz Diniz GrisoliaCésar Augusto Briceño
Mar 15, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yannis AthanasiadisParwez Hossain
Aug 21, 2018·Current Opinion in Ophthalmology·Zhen LiElizabeth Fortin
Dec 21, 2019·Clinical & Experimental Ophthalmology·Adrian T FungPaul Beaumont
Jan 26, 2016·Ophthalmic Plastic and Reconstructive Surgery·Michael J Davies, Peter J Dolman
Mar 9, 2018·International Ophthalmology Clinics·Yao WangPradeep Mettu
Jan 7, 2021·Therapeutic Advances in Endocrinology and Metabolism·Jan LängerichtGeorge J Kahaly
Mar 21, 2021·International Ophthalmology Clinics·Phillip Tenzel, Ronald Mancini
Mar 28, 2021·Orbit·Mythri K RaoBipasha Mukherjee
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