Repercussion of acetylsalicylic acid during fetal development on later renal hemodynamics of rats

Fundamental & Clinical Pharmacology
Leucio D Vieira-FilhoAna D O Paixão

Abstract

Acetylsalicylic acid (ASA) during pregnancy reaches the fetus. It seems important to know possible repercussions of ASA on later renal function of the offspring, as well as repercussions of this drug on factors that may influence fetal development, such as maternal plasma volume and placental oxidative stress. It was evaluated whether ASA changes maternal plasma volume and/or placental oxidative stress, fetal weight and renal function of the offspring at adult life. ASA (100 mg/kg/day, p.o., dissolved in ETOH 10%) or ETOH 10% was administered to Wistar rat dams, from the day 7 to day 20 of pregnancy/parturition. Plasma volume and the placental oxidative stress were evaluated on day 20 of pregnancy, using, respectively, the Evans blue dye and the thiobarbituric acid reactive substances methods. Mean arterial pressure, renal blood flow (RBF) and glomerular filtration rate (GFR) were evaluated in the anesthetized offspring, at the age of 90 days, using a blood pressure transducer, a flow probe and inulin clearance respectively. Plasma volume was 76% (P < 0.05) higher in ASA compared with that in control dams, but placental oxidative stress was the same for both groups. Fetal body weight, the number of nephrons, GFR, RBF and renal ...Continue Reading

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Citations

Jul 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Henriqueta D CardosoAna D O Paixão
Feb 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jennifer R CharltonJ Bryan Carmody
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Jan 11, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Ruud Rg BuetersMichiel F Schreuder
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Jun 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabrina Leverrier-PennaSéverine Mazaud-Guittot

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