Reperfusion plasma contains a neutrophil activator

Annals of Vascular Surgery
I S PatersonC P Shearman

Abstract

Aortic aneurysm repair produces inflammatory mediators, neutrophil activation, and remote organ injury. Reperfusion plasma from these patients produces microvascular injury in an ex vivo chemotactic model. This study investigates the mechanism of this injury. Vena caval blood was obtained before and 15 minutes after aortic clamp removal (n = 16) or at laparotomy (n = 10). Plasma or saline solution was introduced into unit dose chambers fixed atop dermabrasions on the back of depilated anesthetized rabbits. Animals were treated with intravenous saline solution (n = 4); made neutropenic with nitrogen mustard (n = 4); pretreated with the xanthine oxidase inhibitor allopurinol (n = 4); or cotreated intravenously with the free radical scavengers superoxide dismutase (SOD) and catalase (n = 4). Three hours later neutrophil counts (polymorphonuclear cells [PMN]/mm3) and activity (free radical production by flow cytometry), protein leakage, and inflammatory mediators (thromboxane [TX] and leukotriene B4 [LTB4]) were measured. In contrast to control plasma in untreated rabbits, reperfusion plasma produced TX and LTB4 generation (1090 +/- 105 and 794 +/- 91 pg/ml, respectively, p < 0.01), PMN accumulation (1636 +/- 210/mm3, p < 0.01) and...Continue Reading

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Citations

Jan 23, 2016·BioMed Research International·Konstantina KatseniKonstantinos Katsenis
Dec 12, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J BownR D Sayers
Apr 1, 1997·Journal of Vascular Surgery·T F LindsayA Romaschin
Jul 3, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M H W A WijnenR J A Goris
Mar 10, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M H WijnenR M Roumen
May 22, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L L LauC V Soong
Feb 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M C BarryD B Hayes
Dec 31, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A B GroeneveldC E Hack
Apr 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M C BarryD J Bouchier-Hayes
Mar 31, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P V Tisi, C P Shearman
Jan 19, 1999·Vascular Medicine·P V Tisi, C P Shearman
Apr 25, 2000·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·N M ElmarasyB R Hopkinson
Dec 6, 2003·Journal of Neuropathology and Experimental Neurology·D D PearseW D Dietrich

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