Reperfusion therapy for ST-elevation acute myocardial infarction in Eastern Europe: the ISACS-TC registry

European Heart Journal. Quality of Care & Clinical Outcomes
Edina CenkoRaffaele Bugiardini

Abstract

Widespread availability of tertiary hospitals with catheterization facilities, although vigorously promoted, has yet to become a reality in many countries with economy in transition. We sought to evaluate the clinical profile and mortality of patients who were hospitalized with a diagnosis of ST-segment elevation myocardial infarction (STEMI) and either received reperfusion therapy or remained without reperfusion in Eastern Europe. Data were obtained from the International Survey of Acute Coronary Syndromes in Transitional Countries (ISACS-TC; NCT01218776) on STEMI patients admitted to 57 hospitals in Eastern European countries from January 2010 to February 2015. The primary endpoint was 30-day mortality. Of 7982 patients, 65 (0.8%) had a documented contraindication to reperfusion, 5973 (75.5%) received fibrinolysis ( n = 1032) or underwent primary percutaneous coronary intervention (p-PCI; n = 4941), and 1944 patients (24.6%) did not receive any reperfusion therapy. The overall unadjusted 30-day mortality rate was 7.9%. Thirty-day mortality rates were higher in non-reperfusion patients (16.0 vs. 5.0% in the p-PCI group and 7.4% in fibrinolysis group). The strongest factors associated with not attempting reperfusion therapy amo...Continue Reading

Associated Clinical Trials

References

May 20, 2000·JAMA : the Journal of the American Medical Association·L J MorrisonD J Cook
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Kim A EagleUNKNOWN GRACE Investigators
Jun 2, 2005·Annals of Family Medicine·Martin FortinLise Lapointe
Mar 4, 2008·European Heart Journal·Kim A EagleUNKNOWN Global Registry of Acute Coronary Events (GRACE) Investigators
Jun 10, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Gabriel Tatu-ChitoiuRaffaele Bugiardini
Aug 28, 2012·European Heart Journal·Kristian ThygesenUNKNOWN ESC Committee for Practice Guidelines (CPG)
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Jan 15, 2014·European Heart Journal·Steen D KristensenUNKNOWN European Association for Percutaneous Cardiovascular Interventions
May 20, 2015·Atherosclerosis·Raffaele BugiardiniUNKNOWN ISACS-TC Investigators

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Citations

Dec 1, 2017·European Heart Journal·Adam TimmisUNKNOWN ESC Scientific Document Group
Nov 28, 2017·European Heart Journal. Quality of Care & Clinical Outcomes·Adam TimmisPanos Vardas
Sep 2, 2017·Journal of the American Heart Association·Raffaele BugiardiniLina Badimon
Jan 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·Chris P Gale
Dec 6, 2021·Cardiovascular Research·Maria BergamiRaffaele Bugiardini

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