PMID: 12777075Jun 5, 2003Paper

Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids

Journal of Neuro-oncology
Steen J MadsenHenry Hirschberg

Abstract

The response of human glioma spheroids to repetitive 5-aminolevulinic acid-mediated photodynamic therapy (PDT) was investigated. In all cases, light fluences were kept below toxic thresholds to simulate conditions typically found at 1-2 cm depths in brain adjacent to tumor. Significant inhibition of spheroid growth was observed following multiple PDT treatments at sub-threshold light fluences. The effect appears to be insensitive to the treatment intervals investigated (weekly or bi-monthly). In all cases, suppression of growth was observed for the duration of treatment. Low fluence rates (< or = 5 mW cm(-2)) appear to be more effective than high fluence rates (25 mW cm(-2)). No evidence of PDT resistance was found in this investigation.

Citations

Jun 12, 2004·Journal of Biomolecular Screening·Leoni A Kunz-SchughartReinhard Ebner
Jun 22, 2006·Lasers in Surgery and Medicine·Steen J MadsenHenry Hirschberg
Dec 14, 2006·Lasers in Surgery and Medicine·Henry HirschbergSteen J Madsen
Apr 22, 2009·Journal of Molecular Neuroscience : MN·A V Lobanov, A B Uzdensky
Sep 18, 2008·Lasers in Surgery and Medicine·Henry HirschbergSteen J Madsen
Mar 11, 2010·Journal of Biophotonics·Floor van ZaaneDominic J Robinson
Jul 30, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Matías E RodríguezViviana A Rivarola
Feb 18, 2010·Journal of Biophotonics·Steen J Madsen, Henry Hirschberg
Dec 1, 2006·Expert Opinion on Drug Discovery·Divya Khaitan, B S Dwarakanath
Mar 3, 2006·Journal of Neurosurgery·Even Angell-PetersenHenry Hirschberg
Sep 5, 2009·Lasers in Surgery and Medicine·Marlon S MathewsSteen J Madsen
Dec 29, 2012·Molecular Cancer Therapeutics·Maria-Fernanda ZuluagaNorbert Lange
May 28, 2021·DNA Repair·Somayeh Shahmoradi GhaheElżbieta Speina
Dec 17, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maximilian NiyaziClaus Belka

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