Repetitive and profound insulin-induced hypoglycemia results in brain damage in newborn rats: an approach to establish an animal model of brain injury induced by neonatal hypoglycemia.

European Journal of Pediatrics
Dong ZhouRuo-Peng Sun

Abstract

The human neonate is at a higher risk for hypoglycemia-induced neuronal injury than other pediatric and adult patients. Repetitive and profound neonatal hypoglycemia can result in severe neurologic sequelae, of which the mechanisms was not elucidated by hitherto. Moreover, no reliable animal model of brain injury induced by neonatal hypoglycemia is available in order to carry out more research. Therefore, we tried to induce neonatal hypoglycemia in newborn rats by fasting and insulin injection, and then examined the neuronal degeneration after repetitive hypoglycemic insults by Fluoro-Jade B (FJB) staining. Experimental animals were randomly divided into four groups: insulin-treated rats with short hypoglycemia, insulin-treated rats with prolonged hypoglycemia, fasted rats, and control rats. Insulin injection and fasting both could induce consistent hypoglycemia in newborn rats. But from FJB staining results, only in insulin-treated rats with prolonged hypoglycemia could extensive neurodegeneration be detected. We can conclude that FJB staining is a useful method of marking neuronal degeneration in neonatal rats following hypoglycemic brain damage. Repetitive and profound neonatal hypoglycemia can result in extensive neurodegen...Continue Reading

References

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Citations

Jun 20, 2012·The European Journal of Neuroscience·Kevin E ChapmanAmy Brooks-Kayal
Jun 28, 2008·Brain Research·Kathleen EnnisRaghavendra Rao
Feb 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M BrinciottiA Napoli
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Feb 23, 2020·Bioscience Reports·Tian ZhaoGuiyu Sun
Jun 9, 2018·Epilepsia Open·Seda SalarAristea S Galanopoulou

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